White/non-Hispanics and Hispanics had a higher prevalence of current HCV infection (14% and 15%, respectively) compared with black/non-Hispanics (7%) (odds ratio [OR]=2, 95% confidence interval [CI]=1.47-2.93 and OR=2, 95% CI=1.9-2.9). Ever having

injected drugs was the strongest risk factor for HCV infection (OR=20.6, CI=16.4-26.0). Of the participants with current infection, 85% attended their first medical appointment; as of April 2014, over 50% remained in care. Discussion: The community-based testing model successfully identified a large number of persons with HCV infection and linked a high proportion to care. The high prevalence of HCV infection among baby boomers supports the NY Testing Law and CDC recommendations. Expanding this http://www.selleckchem.com/products/OSI-906.html model to more settings with high-risk populations will aid in successfully identifying and linking HCV positive

individuals into care. Disclosures: Eric J. Rude – Grant/Research Support: Vertex, Merck, Bristol Myers ICG-001 research buy Squibb, Orasure, Janssen, Gilead, Kadmon, Boehringer-Ingelheim, Abbott, Genentech The following people have nothing to disclose: Mary Ford, Ashly Jordan, Nirah Johnson, Holly Hagan, Fabienne Laraque, Jay K. Varma Background: The hepatitis C virus (HCV) first identified in 1989 is a highly infectious blood borne virus that has spread extensively globally, especially among people who inject drugs (PWID). The current study uses pooled biological and behavioral data from 8 individual prospective studies of PWID to describe HCV incidence over time (1985-2011), across locales (U.S., Canada, the Netherlands, and Australia). Methods: We used life table methods to estimate the incidence of HCV infection within the first two years of follow-up by locale, and estimated rate ratios to compare infection rates between 上海皓元医药股份有限公司 locales. Results: Of 5,248 participants, 2,891 (55%) tested HCV negative at enrollment; of these, 2,197 (42%) were followed prospectively for a median of 1.2 years (Interquartile range [IQR]: 0.5, 2.6 years); median age at study entry was 25 (IQR, 21, 28), the majority were white (69%) and male (64%). The drug injected

most often included heroin (50%), [meth]amphetamines (18%), cocaine (12%), and other opioids (7%) and varied by locale. During 5,259 person-years observation (pyo) of follow-up, 673 became infected for an estimated overall incidence of 12.8/ 100 pyo (95% CI: 12, 14). HCV incidence was highest within the first 5 years of study observation (14.0/pyo; 95% CI 12, 15). Historical trends in HCV infection rates (≤2 years follow-up) decreased for participants in the Dutch and Australian cohorts, increased for Canadian cohorts, and remained steady for American cohorts across 1985-2011 (table 1). Incidence (≤2 years follow-up) was highest among cohort participants in the U.S. (27.7 / pyo; 95% CI 24, 31), followed by Canada and Australia at 23.6/pyo (95% CI 18, 29) and 12.