2 x 3 x 3 cm in size and it was located within the muscular layer

2 x 3 x 3 cm in size and it was located within the muscular layer of the duodenal wall. The cysts were lined by a single layer of eosinophilic cuboidal epithelial cells that

stained positively for mucin (MUC) 1, MUC6, cytokeratin (CK)7 and CK19 and they stained negatively for MUC2, MUC5AC and CK5/6. Mild, chronic inflammatory reaction around the cystic wall, Brunner’s gland hyperplasia and several clusters of heterotopic pancreatic tissue were noted. We report Baf-A1 cost here on a case of PP and we demonstrated that the pancreatitis was of pancreatic ductal cell origin according to the MUC and CK expression patterns we observed on the immunohistochemical analysis.”
“Objectives Examine factors associated with opioid adverse drug events (ADE) in children. Specific Aims Examine

whether adjuvant nonopioid use is associated with a decreased probability of opioid-ADEs and need for rescue. Background Opioid-ADEs contribute to serious preventable harm for hospitalized children. Adjuvant nonopioid use may mitigate opioid risk postoperatively, yet few studies support this notion. Method This nested casecontrol study included children who required intervention or rescue from opioid-ADEs and procedure-matched controls. Data were recorded from medical records and primary outcomes included serious opioid-ADEs (over-sedation and respiratory depression) and need for rescue (e.g., naloxone, rapid response team). Hierarchical logistic regression (HLR) models examined GDC-0068 clinical trial relationships between factors and opioid-ADEs. Early clinical signs and symptoms of deterioration were examined. selleck chemicals llc Results Twenty five children with opioid-ADEs and 98 children without events were included. ASA-PS remained an independent risk factor (odds ratio, 2.56 [1.09, 6.03]; P = 0.031), while adjuvant nonopioids a risk reduction

factor for opioid-ADEs (OR, 0.16 [0.05, 0.47]; P = 0.001) and need for rescue (0.14 [0.04, 0.47]; P = 0.001). Supplemental oxygen use at PACU discharge was associated with an increased odds of opioid-ADEs (OR, 3.72 [1.35, 10.23]; P = 0.007) and need for rescue (5.5 [1.7, 17.82]; P = 0.002). Conclusions Findings from this study suggest that strategies such as early use of adjuvant nonopioids may reduce risk of opioid-ADEs postoperatively. Furthermore, children who require supplemental oxygen early postoperatively may be at heightened risk of later events.”
“The aim of this study was to characterize the pathogens and their antibiotic susceptibilities in children with catheter-associated urinary tract infection (CAUTI) in order to optimize empirical antibiotic therapy and prophylaxis. From 2001 to 2006, 895 children with an indwelling catheter from 3 hospitals in China were included in this study, of whom 335 (37.4%) had CAUTI. Antimicrobial susceptibility testing of 450 bacterial isolates was performed using the CLSI broth and Kirby-Bauer agar dilution methods.

A pharmacotherapeutic follow-up was carried out among patients wi

A pharmacotherapeutic follow-up was carried out among patients with acute lymphoid leukemia in the maintenance phase of chemotherapy treatment. Data was collected from medical records and patients and/or caregivers’ CDK inhibitors in clinical trials answers to designed interview forms. Nine patients aged 3-14 years were followed. We identified 41 Drug-Related Problems (DRP), classified according to the Second Granada Consensus, varying from 1 to 11 DRY per patient. The most frequently found DRPs were: 16 DRP1 (consequence of not receiving the

medication needed), 12 DRP4 (consequence of a quantitative ineffectiveness), 9 DPR6 (consequence of a quantitative safety problem). Most patients from this study (78%) used the drugs correctly, but only a third of them knew their purpose. It is important that pharmacotherapeutic follow-up continues and is expanded in the institution in order to give more guidance to caregivers and patients.”
“This study was performed to investigate the effects of heat and autoclave treatment on the binding ability of porcine serum albumin (PSA) to IgG and the serum of patients who were allergic to pork. Heat treatment at 100A degrees C for 20 min on PSA was able to decrease the binding ability of PSA to IgG to 52%. The binding ability of PSA to IgG was also reduced to 29% by autoclave click here treatment of PSA at 121A degrees C

for 30 min. The binding ability of PSA autoclaved for 30 min to serum also decreased to 10%. SDS-PAGE and immunoblotting of PSA heated at 100A degrees C for 20 min revealed see more that the intensity of the PSA band decreased and its presence was barely recognized by IgG. In the case of autoclave treatment (for 5 min), PSA was degraded to low-molecular-weight peptides and IgG and serum did not recognize them. Therefore, autoclave treatment can effectively

reduce the allergenicity of PSA.”
“A dc-induced voltage oscillation was observed at room temperature in (Ni(36)Nb(24)Zr(40))(90.1)H(9.9) glassy alloy ribbons of about 1 mm width and 30 mu m thickness and an electrode distance of 20 mm. The I-V characteristic provided evidence of the Coulomb staircase at similar to 300 K, suggesting the existence of macroscopic proton dot tunneling along the Zr(Nb)-H-square-H-Zr(Nb) atomic bond array, where square is the vacancy barrier among clusters. The frequency decreased remarkably with increasing capacitance (C) and resistance (R) at room temperature. Thus the (Ni(36)Nb(24)Zr(40))(90.1)H(9.9) glassy alloy can be regarded as a dc/ac converting device with a large number of nanofarad capacitance.”
“A sensitive and specific liquid chromatography electrospray ionization-mass spectrometry method for determination of tetrahydropalmatine in rat plasma has been developed and validated. Chromatography was performed on a Luna C-18 column (2.1 x 100 mm i.d, 3.0 mu m particle, Phenomenex, USA) with isocratic elution using a mobile phase containing acetonitrile and water with an addition of 10 mmol of ammonium acetate.

Methods: A total of 20,736 infants from Finland, initially in RES

Methods: A total of 20,736 infants from Finland, initially in REST, were followed for RVGE-associated hospitalizations and ED visits in a Finnish extension study (FES) for up to 3.1 years after vaccination (age, similar to 3.5 years).

Results: The FES added >18,500 person-years and captured 150 RVGE-associated

hospitalizations and ED visits (11 RV5; 139 placebo). In REST + FES, RV5 reduced RVGE-associated hospitalizations and ED GDC-0973 research buy visits, regardless of rotavirus serotype, by 94.0% (95% confidence interval [CI] : 91.4%-95.9%) for up to 3.1 years after vaccination. RV5 also conferred significant protection against hospitalizations and ED visits associated with rotavirus serotypes G1 (95.5%; 95% CI: 92.8%-97.2%), G2 (81.9%; 95% CI: 16.1%-98.0%), G3 (89.0%; 95% CI: 53.3%-98.7%), G4 (83.4%; 95% CI: 51.2%-95.8%), and G9 (94.2%; 95% CI: 62.2%-99.9%). Rate reductions (95% CI) in hospitalizations and ED visits during the first, second, and third years of life were 94.0% (90.0%-96.5%), 94.7% (90.7%-97.2%), and 85.9% (51.6%-97.2%), Ion Channel Ligand Library purchase respectively.

Conclusions: RVGE-associated hospitalizations and ED visits remain common in

the second year of life but decrease in the third year of life. RV5 showed sustained protective efficacy against RVGE-associated hospitalizations and ED visits, regardless of rotavirus serotype, for up to 3.1 years after vaccination.”
“Tapping panel dryness (TPD) is a complex physiological syndrome found widely in rubber tree (Hevea brasiliensis) plantations that

causes severe yield loss in natural rubber-producing countries. In an earlier study, we confirmed that there is a negative correlation between HbMyb1 expression and TPD severity. To further investigate the function of HbMyb1 in TPD, HbMyb1 was over-expressed in tobacco controlled by a CaMV 35S promoter. In transgenic plants expressing HbMyb1, cell death induced by UV-B irradiation, paraquat and the hypersensitive reaction to necrotrophic fungal infection (Botrytis cinerea) was suppressed with a close correlation between HbMyb1 protein levels and the extent of suppression. In addition the nuclear condensation and degradation were observed in laticifer cells of TPD trees, while the nucleus of laticifer cells of healthy trees was morphologically normal. On the basis of the results described buy INCB024360 above, we propose that HbMyb1 maybe suppress stress induced cell death in rubber trees. (C) 2011 Elsevier Masson SAS. All rights reserved.”
“The growth of Au-silica nanocomposite film is simulated in the framework of kinetic three dimensional lattice Monte Carlo simulations considering the basic phenomena in the deposition process. In case of co-sputter deposition, the growth kinetics of nanoparticles has been studied taking into consideration the effect of the energetic sputtered species reaching the surface of the film during deposition.

Endothelial function was assessed by non-invasive finger plethysm

Endothelial function was assessed by non-invasive finger plethysmography, previously validated by the US Food and Drug Administration (Endopath; Itamar Medical Ltd., Cesarea, Israel).

Results. Endothelial function was significantly reduced in ex-ELBW subjects compared to C (1.94 +/- 0.37 vs 2.68 +/- 0.41, p < 0.0001). Moreover, this function correlated significantly with gestational age (r = 0.56, p < 0.0009) and birth weight (r = 0.63, p < 0.0001).

Conclusions. The results

obtained reveal a significant decrease in endothelial function of ex-ELBW subjects compared to controls, underlining a probable correlation with preterm birth and low birth weight. Taken together, these results suggest that an ELBW may underlie the onset of early circulatory dysfunction predictive of increased cardiovascular risk.”
“Previous studies have demonstrated that amino acid infusions exert enhanced thermogenic effects during general anesthesia. This https://www.selleckchem.com/products/liproxstatin-1.html study was Selonsertib purchase conducted to investigate whether amino

acid infusions started after development of intraoperative core hypothermia can accelerate rewarming.

Twenty-two patients scheduled for major abdominal surgery were included in this study. When tympanic temperature reached 35.5A degrees C, patients were randomly assigned to receive amino acids (amino acid group; n = 11) or saline (saline group; n = 11). A continuous infusion of a mixture of 18 amino acids or saline was started at 200 ml h(-1). Tympanic, forearm, and digit temperatures were recorded. Forearm minus fingertip skin-surface temperature gradients (temperature gradient) were calculated. Postoperative shivering was also evaluated.

Tympanic membrane temperature and temperature gradient were similar between the two groups at each time point during the study period. Temperature gradient at extubation in the amino acid group was significantly lower than in the saline group although tympanic temperature at extubation was similar between the two groups. Postoperative

shivering score was significantly lower in the amino acid group than in the saline group.

Amino acid infusions started after development of intraoperative core hypothermia failed to accelerate HKI-272 rewarming. However, amino acid infusions reduced the incidence of postoperative shivering. Use of amino acid infusions to reduce thermoregulatory vasoconstriction at emergence might contribute to a decrease in the development of postoperative shivering.”
“Introduction: Dopaminergic medication administered to ameliorate motor symptoms of Parkinson’s disease is associated with impulse control disorders, such as pathological gambling, hypersexuality, compulsive buying, and binge eating. Studies indicate a prevalence of impulse control disorders in Parkinson’s disease of 6-16%.

Objective: To estimate the prevalence of impulsive and compulsive behaviors among Danish patients with Parkinson’s disease and to explore the relation of such behavioral disorders to depression and personality.

Some dermal/epidermal substitutes have been applied to the treatm

Some dermal/epidermal substitutes have been applied to the treatment of patients. Cultured corneal epithelial cells have been characterized and more complete corneal substitutes are being designed. Long-term clinical results

on the transplantation of cultured corneal stem cells for the treatment of limbal stem cell deficiency have been reported.


Advances in tissue engineering for the development of substitutes that will benefit patients suffering from skin or corneal stem cell deficiencies are reviewed. These products are often a combination of cells, scaffolds and other factors. Key considerations in the development of corneal and skin substitutes for clinical applications are discussed.”
“Purpose of review

This review focuses on the immunogenicity

AZD1208 cost of embryonic stem cell (ESC)-derived progenitors and the impact of the immune response on applications of cell replacement this website therapy (CRT). Possible strategies to induce immunological tolerance to ESC-derived progenitor cells will also be discussed.

Recent findings

Evidence for the differential epigenetic control of major histocompatibility (MHC) and antigen processing molecules in ESCs and differentiated ESCs has recently been described. The presence of T cells recognizing the pluripotency-associated transcription factor octamer-binding transcription factor 4 (OCT4) in healthy patient-derived peripheral blood mononuclear cells adds further complexity to the immune response against ESCs and ESC-derived progenitors.


Although ESCs and ESC-derived progenitors appear to exert some level of immune privilege in specific circumstances,

these allogeneic cells are indeed recognized by the immune system and can be subject to mechanisms of rejection. Herein, we discuss the importance of the recent reports describing an immunosuppressive capacity of ESCs, and the epigenetic control of MHC in ESCs and how these characteristics may be harnessed in the development of strategies to induce immunological tolerance.”
“Purpose of review

The induced pluripotent stem (iPS) cells from patient’s somatic cells could be a useful Cell Cycle inhibitor source for drug discovery and cell transplantation therapies. However, there are still several problems to be solved in terms of safety concerns. We herein summarize the current knowledge about iPS cells and the obstacles that must be overcome before the cells can be used for medical applications.

Recent findings

Recent progress has enabled us to generate integration-free iPS cells from noninvasive tissues. Several studies have also uncovered differences in iPS cells and ES cells in terms of gene expression, epigenetic modification, and differentiation potentials. Tissue origin affects the quality of iPS cells. However, in a rodent disease model, the transplantation of differentiated cells derived from iPS cells ameliorated their symptoms.

The difference for the rARA C2-C7 between the PC (mean 20 7) and

The difference for the rARA C2-C7 between the PC (mean 20.7) and HTV (mean 9.2) yielded significance (P = 0.01). But, concerning restriction of flexion/extension at the AAC, there was no statistical significant difference for the rSRA C1-C2 between the PC and HTV (P = 0.3). The PC (mean 1.3) was even superior to the HTV (mean, 3.3) in restricting sagittal motion at C1-C2. In comparison to normal atlantoaxial motion was restricted

by 88.5% with the PC and 70.8% with the HTV. In light of the results and a selected review of literature, a treatment algorithm for the elderly patient with odontoid fracture is presented.

Conclusion. Under the extremes of flexion and extension bendings, the current study demonstrated that there was no significant difference in restriction of sagittal motion at C1-C2 when using the PC instead of the HTV in a group of 20 young

selleck products normal adults. In light of the current biomechanical data and a selected review of literature, it is concluded that the use of a PC is sufficient for the treatment of stable odontoid fractures.”
“SETTING: Occupational asthma (OA) is most likely to develop in the very early years of exposure.

OBJECTIVE: To describe the early incidence of OA among bakers/pastry-makers (BP) and hairdressers and to explore the role of atopy.

DESIGN: Following a retrospective follow-up design, subjects were invited to undergo telephone interviews. Those who declared work-related respiratory or rhinitis symptoms and a sample group of others were offered a medical visit for OA investigations. Data from interviews and from medical visits were Emricasan used to estimate A-1155463 chemical structure the incidence of OA according to increasing durations of exposure.


A total of 866 subjects were interviewed (mean age 25.3 years, 43.8% females), of whom 282 underwent a medical visit. Total estimated incidence rates of ‘confirmed or probable’ OA during the first 12 years of exposure were high in BP (2.63 per 100 person-years [py]) and in hairdressers (0.58/100 py), particularly in the first 4 years. Atopy is a strong risk factor for incidence among BP but, irrespective of the occupational sector, it does not influence the timing of OA symptoms.

CONCLUSION: OA symptoms occur soon after the start of exposure. Our results suggest that atopy does not precipitate the occurrence of symptoms in two different allergen exposure settings.”
“P>In recent years, the importance of appropriate intra-operative anesthesia and analgesia during cardiac surgery has become recognized as a factor in postoperative recovery. This includes the early perioperative management of the neonate undergoing radical surgery and more recently the care surrounding fast-track and ultra fast-track surgery. However, outside these areas, relatively little attention has focused on postoperative sedation and analgesia within the pediatric intensive care unit (PICU).

Based on the observed manner of void growth and the estimated act

Based on the observed manner of void growth and the estimated activation

energies, the authors propose that mass transport on the HfO2 surface is responsible for void nucleation in the HfO2 films on Ge. The authors also compare the present results with the previous studies on HfO2/Si structures, and suggest that similar surface process leads to the local Hf silicidation. (C) 2010 American Institute of Physics. [doi:10.1063/1.3415542]“
“Purpose: It has long been recognised that effective cancer care is not possible without multi-professional team working. Collaboration and multi-professional working however are known to be less than straightforward. see more This project aimed to use a collaborative approach to explore

and facilitate professional groups to work together more effectively in the field of children’s cancer care.

Method: Based on an earlier project in Italy, a three-year seminar series was organised involving both a doctor and nurse from 15 paediatric haematology/oncology units across Europe. Participants had to be able to speak English and commit to participate in annual seminars as well as the development and implementation of a local project to enhance doctor-nurse collaboration in their own unit. Appreciative Inquiry was the methodological approach used to address organisational as well as interpersonal change.

Results: Fifteen doctor nurse teams were initially selected from a range of different countries, check details and 10 completed the project. Key outcomes reported include implementation and successful completion of projects, publication click here of the results achieved, participant satisfaction with improvements in collaboration. Feedback from participants would suggest that change had been implemented and possibly sustained.

Conclusions: Active involvement and group support were required for success. More

formal relationships needed to be activated with participating centres to guarantee support for those involved in implementing lasting change. A web-based resource to allow other programmes and centres to use the resources developed has been made available. The same approach, we believe, could be used to improve multi-professional working in the care of other childhood illnesses. (C) 2013 Elsevier Ltd. All rights reserved.”
“P>Recently, the applicability of lungs from drowned victims for transplantation has been anecdotically described in literature. However, no data exist about hazards or limitations. Herein, we describe a case of lung transplantation from a submersion victim and the subsequent development of an Aeromonas hydrophila infection in the implanted organ. Based on this case we propose standard procedures, which should be followed when considering drowned donor lungs, in order to minimize risks for infectious complications.

Diagnostic performance characteristics were derived (AUROC, sensi

Diagnostic performance characteristics were derived (AUROC, sensitivity and specificity, predictive values), and clinical utility modelling performed to determine the proportion of biopsies that could have been avoided if ELF test was used in this patient group. It was possible to simplify the original ELF test without loss of performance and the new algorithm is reported. The simplified ELF test was able to predict severe fibrosis [pooled AUROC of 0.85 (95% CI 0.81-0.89)] and using clinical utility modelling to predict severe fibrosis (Ishak stages 4-6; METAVIR stages 3 and 4) 81% of biopsies could have been avoided (65% correctly). Issues of spectrum effect in diagnostic test evaluations

are discussed. In 17DMAG in vivo chronic hepatitis C a simplified ELF test can detect severe liver fibrosis with good accuracy.”
“P>Several lines of evidence suggest that the identity of floral organs in angiosperms www.selleckchem.com/products/lcl161.html is specified by multimeric transcription factor complexes composed of MADS-domain proteins. These bind to specific cis-regulatory

elements (‘CArG-boxes’) of their target genes involving DNA-loop formation, thus constituting ‘floral quartets’. Gymnosperms, angiosperms’ closest relatives, contain orthologues of floral homeotic genes, but when and how the interactions constituting floral quartets were established during evolution has remained unknown. We have comprehensively studied the dimerization and DNA-binding of several classes of MADS-domain proteins from the gymnosperm Gnetum gnemon. Determination of protein-protein and protein-DNA interactions by yeast two-hybrid, in vitro pull-down and electrophoretic mobility shift assays revealed complex patterns of homo- and heterodimerization among orthologues of floral homeotic class B, class C and class E proteins and B(sister) proteins. Using DNase I footprint assays CT99021 molecular weight we demonstrate that both

orthologues of class B with C proteins, and orthologues of class C proteins alone, but not orthologues of class B proteins alone can loop DNA in floral quartet-like complexes. This is in contrast to class B and class C proteins from angiosperms, which require other factors such as class E floral homeotic proteins to ‘glue’ them together in multimeric complexes. Our findings suggest that the evolutionary origin of floral quartet formation is based on the interaction of different DNA-bound homodimers, does not depend on class E proteins, and predates the origin of angiosperms.”
“Bacillus anthracis, the etiologic agent for anthrax, secretes edema factor (EF) to disrupt intracellular signaling pathways. Upon translocation into host cells and association with a calcium sensor, calmodulin (CaM), EF becomes a highly active adenylyl cyclase (AC) that raises the intracellular concentration of cyclic AMP (cAMP). Growing evidence shows that EF plays a key role in anthrax pathogenesis by affecting cellular functions vital for host defense. This strategy is also used by Bordetella pertussis, a bacterium that causes whooping cough.

Brain functional studies in these patients have demonstrated an o

Brain functional studies in these patients have demonstrated an orbitofrontal hypometabolism, persistent after overuse cessation. Orbitofrontal dysfunction is also present in addiction and thus could predispose migraineurs to medication overuse. The aim of this study was to investigate if orbitofrontal dysfunction can be demonstrated in patients with chronic migraine and medication overuse by performing a systematic neuropsychological evaluation focused on tests that assess frontal lobe function. Second, to establish whether it is related to the outcome of these patients. We prospectively studied 42 chronic

migraine patients with medication overuse, 42 episodic migraineurs and 41 controls on a battery of neuropsychological tasks evaluating the orbitofrontal and dorsolateral selleckchem functioning. Depression, anxiety, and personality

Selleckchem HSP inhibitor traits were also assessed. Chronic migraineurs with medication overuse showed a significant impairment in orbitofrontal task performance and higher depression scores as compared to episodic migraineurs and controls. Dorsolateral dysfunction was present in both groups of migraneurs, who also had higher rates of anxiety as compared to controls. After 1 year of follow-up, migraine patient’s outcome was classified according to their medication overuse status. A negative outcome that included persistent or new-onset medication overuse was present in 34% of migraineurs Selleck Etomoxir and was associated with baseline poor orbitofrontal task performance, and with mild dorsolateral dysfunction, higher rates of depression, anxiety and neuroticism-anxiety traits. Formal education and years with migraine did not influence outcome. Orbitofrontal dysfunction is present in patients with chronic migraine and medication overuse, and associates with a poor outcome at 1 year of follow-up. Neuropsychological evaluation in migraine may help to detect patients prone to overuse so that appropriate therapeutic attitudes can be taken.”
“Improvement of survival in patients with beta-thalassemia

has allowed several clinical morbidities to manifest, including renal complications. Patients may experience proximal tubular dysfunctions and abnormalities in glomerular filtration rate. Several risk factors have been proposed. Hypoxia may lead to renal damage with resulting proximal tubular epithelial cell dysfunction and interstitial fibrosis, while anemia induces renal hemodynamic changes. Iron overload secondary to regular transfusion therapy can also result in an increase in oxidative stress and direct cytotoxicity to the kidney. Moreover, the use of certain iron-chelating agents is associated with a transient, nonprogressive increase in serum creatinine levels. However, most available evidence comes from small, cross-sectional studies. Longitudinal follow-up of patients is needed to better understand the mechanisms of renal abnormalities in this patient population.

It suggests a possible strategy for the brain to extract rarely-o

It suggests a possible strategy for the brain to extract rarely-occurring stimulus values, while concentrating neuronal resources on the most

commonly-occurring situations.”
“We have examined the responses of GaAs, InP, InAs, and AlAs to 30 keV focused ion beam (FIB) irradiation and applied a unified model that consistently explains the observed effects. Nanodots were observed to form on GaAs, InP, and InAs under irradiation at normal incidence, while nanodots are not observed on AlAs. The FIB response and nanodot formation behavior of each material is discussed with regard to a few basic material properties and a model for nanodot creation and growth by the action of preferential sputtering and Ostwald ripening. The model predicts the development of a stable average nanodot size with increasing ion dose, with the average nanodot GSK1904529A size depending on the excess group III adatom yield, adatom surface diffusion rate, and surface tension.

These predictions qualitatively agree with the experimentally observed trends for GaAs and InP. They also agree for the initial nanodot formation on InAs, but this material system exhibits a sudden transition in the nanodot size distribution. The model predicts that nanodots will have difficulty forming and growing on AlAs, which is also in agreement with our experimental results. (C) 2011 American Institute of Physics. [doi:10.1063/1.3530839]“
“Chronic hepatitis C (HCV) infection afflicts millions of people worldwide. While antiviral treatments are effective for some patients, many either cannot or choose not to receive antiviral high throughput screening treatment. Education about behavioural click here changes like alcohol avoidance and symptom management, in contrast, is universally recommended, particularly in HCV-infected persons from disadvantaged groups where liver risk factors are most prevalent. Self-management interventions are one option for fostering improved HCV knowledge and health-related quality of life (HRQOL). One hundred and thirty-two patients with VA with HCV (mean age of 54.6, 95% men, 41%

ethnic minority, 83% unmarried, 72% unemployed/disabled, 48% homeless in last 5 years) were randomized to either a 6-week self-management workshop or an information-only intervention. The weekly 2-h self-management sessions were based on cognitive-behavioural principles and were adapted from an existing self-management programme that has been efficacious with other chronic diseases. HCV-specific modules were added. Outcomes including HRQOL, HCV knowledge, self-efficacy, depression, energy and health distress were measured at baseline and 6 weeks later. Data were analysed using ANOVA. When compared to the information-only group, participants attending the self-management workshop improved more on HCV knowledge (P < 0.001), HCV self-efficacy (P = 0.011), and SF-36 energy/vitality (P = 0.040). Similar trends were found for SF-36 physical functioning (P = 0.055) and health distress (P = 0.