\n\nMETHODS: Ocular-fluid samples obtained from patients diagnosed with postoperative endophthalmitis were submitted to a microbiology laboratory for culture. One milliliter of microbial isolate suspension with a McFarland standard turbidity of 0.5 was mixed with 1 mL of 1%, 2%, 5%, and 10% povidone-iodine solutions.
After 1 minute, 5 minutes, and 15 minutes of exposure at 37 C, each solution was transferred to appropriate culture media and incubated at 37 C for 24 hours.\n\nRESULTS: Organisms were isolated in 30 (68%) of the 44 patients evaluated. Coagulase-negative Staphylococcus was identified in 14
PXD101 in vivo cases (47%), Streptococcus URMC-099 species in 8 cases (27%), Staphylococcus aureus in 5 cases (17%), Bacillus cereus in 2 cases (6%), and Pseudomonas aeruginosa in 1 case (3%). Higher povidone-iodine concentrations and longer exposure times were more effective than lower povidone-iodine concentrations or shorter exposure in preventing growth of bacterial isolates. The most effective regimens were 5% povidone-iodine for 15 minutes and 10% povidone-iodine for at least 5 minutes. With a high bacterial load, 13% of bacterial isolates remain viable after exposure to 10% povidone-iodine, even with a long exposure time.\n\nCONCLUSION: Results indicate that using 5% povidone-iodine for 15 minutes or 10% povidone-iodine for 5 minutes can prevent the growth of most post-cataract surgery endophthalmitis bacterial Alvocidib clinical trial isolates.”
“A diode laser (LD)
clad-pumped narrow linewidth all-fiber Tm3+-doped fiber laser is reported with a maximal output power of 27W at 1.947 mu m. By successively splicing an LD pigtail fiber, a single-mode Tm3+-doped fiber, and a multi-mode Tm3+-doped fiber, the fiber laser has 70 pm narrow linewidth output, and a high slope efficiency of nearly 47.5% with respect to the launched pump power. The high reflectivity fiber Bragg gratings, which are directly written into the single-mode Tm3+-doped fiber core by the 800 nm femtosecond pulsed laser, act as the high reflectivity coupler. The output laser has diffraction-limited beam quality with a factor M-2 of 1.29, when the output laser power is nearly 27 W.