Asci (56–)82–101(–118) × (3–)5–7(–9) μm (n = 314), stipe (4–)6–22

Asci (56–)82–101(–118) × (3–)5–7(–9) μm (n = 314), stipe (4–)6–22(–33) μm (n = 31) long. Ascospores hyaline, verruculose to verrucose with verrucae ca 0.5 μm long and diam, cells dimorphic; distal cell (3.3–)4.0–5.2(–7.5) × (3.2–)3.8–4.5(–5.5) μm (n = 411), subglobose, oval to wedge-shaped; proximal cell (3.4–)4.5–5.8(–8.0) × (2.7–)3.3–4.0(–5.3) μm (n = 411), oblong Momelotinib clinical trial to wedge-shaped, lower end broadly rounded. Cultures and anamorph: optimal growth at 25°C on all media, no growth at 35°C. On CMD after 72 h 14–17 mm at 15°C, 39–41 mm at 25°C, 14–24 mm at 30°C; mycelium covering the plate after

5–6 days at 25°C. Colony hyaline, thin, circular, not zonate; hyphae loosely arranged. Autolytic activity inconspicuous, coilings abundant in some isolates. Aerial hyphae scarce during fast growth, becoming abundant, particularly towards the margin, broad zone at the margin becoming downy. A diffuse greenish yellow pigment, 1B2–6, 2A3, 3B4, 29A2–3, often diffusing through the entire culture after 1–2 weeks. Typically a distinct coconut-like odour formed. Chlamydospores noted after

5–6 days, uncommon, terminal or intercalary, (7–)8–12(–16) × (6–)7–11(–13) μm, l/w check details (0.9–)1.0–1.3(–1.5) (n = 28), globose or subglobose; size dependent on hyphal width. Conidiation starting after 2 days, developing slowly, turning pale to dark green, 28A4–5 to 27F5–8, after 5 days; typically effuse, spreading from the centre and particularly concentrated at the distal and lateral margins, often followed by the formation of polymorphic, loose shrubs or tufts of 0.2–1.5 mm diam, confluent up to 3 × 2 mm, find more sometimes in up to three concentric rings or evenly or irregularly disposed. Sometimes small pustules Erastin solubility dmso formed

early in proximal areas of the plate. Inoculation in the middle of the plate often resulting in more regular distribution of tufts or pustules. Conidiophores typically visible at the surface of the pustules. Shrubs, tufts or pustules arising on a thick-walled and verrucose stipe to ca 11 μm wide, of varying length, asymmetrically branched into thick and long primary branches 2–3 times further branched, spanning a loose reticulum of long and thin, paired or unpaired conidiophores. Conidiophores not conspicuously curved or sinuous, comprising a) a well-discernible main axis with a tree-like terminus and short, more or less straight, regularly tree-like side branches, often paired and mostly inclined upwards along the axis or b) particularly in effuse, more simple conidiophores, a distinct or indistinct main axis with or without paired or unpaired, long, straight or curved, side branches in right angles or inclined upwards, terminating in one or two phialides; phialides appearing to proliferate percurrently, often resulting in a submoniliform chain of 2–6 cells swollen in the middle and more or less conspicuously constricted above and below the middle.

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