For example, Lin excluded some participants who had participated in >2 h/week of exercise and others with calcium intake >1,200 mg/day. Since exercise and calcium intake may be related to BMD, exclusion of these women could have
affected their findings. Moreover, women included in Lin’s study weighed less on average than those in our study (60 vs 73 kg, respectively). Our findings do mirror those of Henry et al. who observed in a sample of 68 white women that peak volumetric BMD was attained by 29 years of age . We also examined peak values in black and Hispanic women and noted that these women continued www.selleckchem.com/products/jib-04.html to exhibit an increase in spinal BMD values until 33 years of age. However, it should be noted that we did not have data on women over age 33, so we were not able to determine if peak values occurred at 33 years or at a later point in time. If minority women continued to increase their BMD after this point, racial differences in the timing of peak values may actually be larger than we observed. BTK pathway inhibitors studies on Selleckchem DMXAA postmenopausal women have shown that Hispanic women are at lower risk of osteoporosis and fractures than whites [34, 35]. One reason
suggested for this lower risk among Hispanics is that the BMD of older Hispanic women is greater that that of whites [35, 36]. We observed, however, that white women actually have greater BMD than Hispanics at both the lumbar spine and femoral neck during adolescence. In fact, the greater BMD observed in Hispanic women as compared with whites later in life is not apparent until 29 years of age at the lumbar spine and 20 years of age at the femoral neck. This change is due to an earlier peak and more rapid decline in BMD following their
peak BMD among whites. It is most likely the continuation PJ34 HCl of this trend that places white women at much higher risk of fractures later in life than their Hispanic counterparts. Thus, it appears that one approach to osteoporosis prevention may be to determine why this rapid decline occurs among white women and attempt to slow the process during their reproductive years rather than waiting to intervene once osteoporosis has already occurred. Similar to the study conducted by Lin et al. , we did not observe a correlation between dietary calcium intake and BMC or BMD. This may have been the result of our study design. While most interventional studies of young healthy women have shown a correlation [37–40], longitudinal and cross-sectional studies have reported inconsistent results [26, 41–43]. A meta-analysis based on mostly cross-sectional studies showed a weak correlation coefficient (0.13) . The lack of correlation between bone health and calcium intake may also have resulted from measurement error if women incorrectly reported portion sizes or types of food consumed.