(C) 2011 American Institute of Physics. [doi:10.1063/1.3611396]“
“Purpose: To determine whether any abnormality in serum bone markers is related to bisphosphonate-induced osteonecrosis of the jaw.
Materials and Methods: we obtained serum bone markers and other relevant endocrine assays on 7 patients with osteonecrosis of the jaws (ONJ). The assays were C-telopeptide, N-telopeptide, bone specific alkaline phosphatase, osteocalcin, intact parathyroid hormone, T3, T4, TSH, and vitamin D 25 hydroxy. Diagnostic
criteria for ONJ were those formulated by the American Association of Oral and Maxillofacial Surgeons.
Results: Five of our patients were women. Two had metastatic breast cancer and had been treated with zoledronic acid; I had also received Emricasan chemical structure pamidronate. Three others had osteoporosis and had been treated with daily
alendronate. One man had metastatic prostate cancer treated with zoledronic acid. Another man had Gaucher’s disease treated with zoledronic acid. All patients had been withdrawn from bisphosphonate for at least 6 months. None was taking or had taken corticosteroids. None of the lesions had shown any significant healing and all were still causing the patients considerable distress, yet the bone markers were within the normal range as measured in our laboratory, except for intact parathyroid hormone, which 4-Hydroxytamoxifen in vitro was slightly elevated in I case of metastatic breast cancer (177 pg/mL).
Conclusions: Acalabrutinib supplier We hypothesize that matrix metalloproteinase 2 (MMP2) is a candidate gene for bisphosphonate-induced ONJ for 3 reasons: 1) MMP2 is associated with bone abnormalities which could be related to ONJ. 2) Bisphosphonates are associated with atrial fibrillation, and MMP2 is the only gene known
to be associated with both bone abnormalities and atrial fibrillation. 3) A network of disorders and disease genes linked by known disorder-gene associations indicates that cardiovascular disease and bone disease are closely related, suggesting that a single drug such as bisphosphonate, acting on a single gene, MMP2, could have both bone and cardiovascular side effects different from the osteoclast inhibition that is characteristic of bisphosphonate. (c) 2009 American Association of Oral and Maxillofacial Surgeons”
“Background and Aims: To assess the influence of body composition changes on circulating serum visfatin after following 12 weeks of energy restricted diet intervention. We also examined the possible role of visfatin in glucose metabolism and in obesity-associated low-grade inflammation.
Methods and Results: A total of 78 obese (BMI 34.0 +/- 2.8 kg/m(2)) women aged 36.7 +/- 7 y volunteered to participate in the study. We measured by DXA body fat mass (FM) and lean mass (LM).