Finally, laborious data processing is needed for each patient to accurately co-register the acquired MR/CT exams, delineate all VOIs and obtain, by home-made software, a quantification of hyper-/hypo-perfused sub-volumes in the lesion. The proposed method of analysis not being included in routine
measurements, our results are not easily reproducible by other research groups for further validation. Conclusions In summary, our results underline the utility SHP099 to quantify the variations of the entire distribution of CBV values in the tumor, by the use of metrics based on histogram analysis. We found that an improvement in hypoxia after a single dose of bevacizumab was a predictor of a greater reduction in T1-weighted contrast-enhanced volumes at first follow-up. We Momelotinib propose that a quantification of changes in necrotic intratumoral regions may be considered as an alternative imaging biomarker of the tumor response to anti-VEGF therapies. Acknowledgments The authors are indebted to Roberto Baldolini and Gaetano Fetonti for Fedratinib purchase their continued technical assistance and to Mrs P.I. Franke for her assistance with the English transcript. References 1. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R: A multivariate
analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001, 95:190–198.PubMedCrossRef 2. Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.PubMedCrossRef GPX6 3. Park JK, Hodges T, Arko L, Shen M, Dello Iacono D, McNabb A, Olsen Bailey N, Kreisl TN, Iwamoto FM, Sul J, Auh S, Park GE, Fine HA, Black PM: Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol
2010, 28:3838–3843.PubMedCrossRef 4. Jain RK: Antiangiogenic therapy for cancer: current and emerging concepts. Oncology 2005, 19:7–16. ReviewPubMed 5. Vredenburgh JJ, Desjardins A, Herndon JE, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS: Bevacizumab plus irinotecan in recurrent glioblastoma multi- forme. J Clin Oncol 2007, 25:4722–4729.PubMedCrossRef 6. Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K, Park J, Albert PS, Fine HA: Phase II trial of single- agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009, 27:740–745.PubMedCrossRef 7. Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM: Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.