was significantly higher at M5, M6, M7, M8 and M9 of recovery compared to M1 (rest) in CP and significantly increased at M5 of recovery compared to M1 (rest) in EP. Discussion The results obtained in the present study demonstrated that the hydration protocol, despite producing lower alterations in the HRV indices, was insufficient to significantly influence HRV indices during physical exercise. However, during the recovery period it induced significant changes in the cardiac autonomic modulation, promoting faster recovery of HRV indices. During exercise, the analysis of RMSSD (ms) and HF (nu), which predominantly reflects the parasympathetic tone of the ANS , showed higher but not significantly increased values when isotonic solution was administered.
Studies indicate that factors linked to decreased vagal modulation in dehydrated individuals Epigenetics Compound Library manufacturer include attenuation of baroreceptor responses, difficulty in maintaining blood pressure and elevated levels of plasma catecholamines during exercise [10, 23, 24]. We expected that these factors may have influenced the lower values of RMSSD (ms) and HF (nu) in CP. Additionally, during exercise SNS activity predominated over vagal activity in both CP and EP. This mechanism occurs to compensate the body’s demands when exposed to exercise . The increase in HR due to increased metabolism is FK506 solubility dmso associated with reduced global HRV
, which was also observed in our study. The SDNN index (ms), which reflects global variability, i.e., both vagal and sympathetic modulation , was reduced during exercise. The isotonic solution intake produced a smaller, though statistically insignificant, reduction in this index. It is possible that factors leading to the reduction of vagal modulation in dehydrated individuals [10, 23, 24] influenced the SDNN (ms) responses. Reduction in global HRV is expected during exercise , since it increases oxyclozanide heart rate, stroke volume, cardiac output and systolic blood pressure, in order to supply the metabolic requirements. This mechanism may explain the LF (nu) increase during exercise, an index that is predominantly modulated by the sympathetic activity , and also the LF/HF ratio increase, which expresses the sympathovagal balance . According to Mendonca et al., , the increase in the spectral indices suggests sympathetic activation during exercise at low and moderate intensities. Javorka et al.,  reported similar findings – they investigated the HRV of 17 individuals subjected to 8 min of the step test at 70% maximal potency, and reported reduced SDNN (ms), RMSSD (ms) and HF and increased LF during exercise. During exercise, as a consequence of reduced cardiac vagal activity, the reduction of global HRV is accompanied by a decrease in absolute power (ms2) of the spectral components .