Methods: Experts in pediatric resuscitation developed two MCQ exams using a set of pre-determined learning objectives. After a single center
pilot, the exam was used as an assessment of cognitive skills in the EXPRESS study, a multicenter trial examining the use of scripted debriefing and high-fidelity simulation in pediatric resuscitation education. Results from the MCQ in the pre-intervention phase of the EXPRESS study were used to assess the reliability and validity of the MCQ examination. In addition, an Exploratory Factor Analysis (EFA) was carried to assess the underlying structure of the PALS-based learning objectives.
Results: 435 health care professionals completed the MCQ examination with an average Selleckchem Cl-amidine score of 69.3%. Significantly higher examination results were seen in physicians vs. non-physicians, senior vs. junior physicians and participants with up-to-date PALS certification. The EFA results indicated four distinct categories of items were assessed.
Conclusion: This short MCQ examination demonstrated reasonable reliability and construct validity. It may be useful to assess pediatric resuscitation knowledge in future studies or courses. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Experimental data suggest that the RAD001 price B-cell antigen CD20 may play
a significant role in the pathogenesis of many diseases including glomerular diseases. These and other findings underpin PDGFR inhibitor the central concept of B-cell-depleting therapies that target CD20 antigen as treatments for lupus nephritis, idiopathic membranous nephropathy, focal segmental glomerulosclerosis, cryglobulinemic glomerulonephritis,
antibody mediated renal allograft rejection and recurrent glomerulonephritis in renal allograft. Use of rituximab as a B-cell depleting therapy has been associated with clinical improvement and has emerged as a possible adjunct or alternative treatment option in this field of nephrology.”
“Three new acetylated anthraquinone glycosides (1-3) were isolated from the seed of Cassia obtusifolia, together with one parent anthraquinone glycoside (1a). Their structures were determined on the basis of spectroscopic methods and physicochemical properties as obtusifoline-2-O–d-2, 6-di-O-acetylglucopyranoside (1), obtusifoline-2-O–d-glucopyranoside (1a), obtusifoline-2-O–d-3, 6-di-O-acetylglucopyranoside (2), and obtusifoline-2-O–d-4, 6-di-O-acetylglucopyranoside (3).”
“Objective To compare the tear-film osmolarity of normal cats and cats with conjunctivitis.
Animal studied The population consisted of shelter, research, and privately owned cats.
Procedures Cats were classified as normal or having conjunctivitis. An ophthalmic examination including Schirmer tear test (STT), fluorescein staining, tear-film break-up time (TFBUT), intraocular pressure (IOP), and slit-lamp biomicroscopy of the anterior segment was performed. The severity of conjunctivitis was graded and assigned a numerical score.