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65. Rambaut A: Molecular evolution, phylogenetics and epidemiology: Tracer. 2009. [http://​tree.​bio.​ed.​ac.​uk/​software/​tracer/​] Competing interests The authors declare no competing interests; financial or otherwise. Authors’ contributions Conceived the study: RMW. Designed and performed the practical experimental work: SM, MY, DCLB, YBH, WKL, RMW. Designed and performed the computational analyses: SM, MY, YCFS, DCLB, GJDS, RMW. Wrote the manuscript: SM, MY, YCFS, DCLB, GJDS, WKL, RMW. All authors have read and approved the final manuscript.”
“Background Lantibiotics are ribosomally synthesized peptides produced by Gram-positive bacteria that frequently exhibit potent antimicrobial activities against other bacteria. Nisin A (nisin) is the most intensively investigated lantibiotic, and was first discovered in 1928 [1]. It has a long history of safe use in the food industry and is approved by the US Food and Drug Administration, by WHO and by the EU (as natural food preservative E234) [2–4].

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