This disease may affect daily life activities and health-related quality of life in adult patients,30 as observed herein. Remarkably, type 1 leprosy reactions with nerve SCH-900776 function impairment were related to severe disease,5 and these abnormalities were also associated with musculoskeletal manifestations, indicating a simultaneous involvement of nerves and joints
that needed immunosuppressant and multibacillary treatment. Moreover, these patients could present permanent joint damage with swan neck deformities, mallet finger, and/or ulnar drift,10 which requires a rigorous and prolonged follow-up. In conclusion, this was the first study to identify a high frequency of musculoskeletal manifestations associated with nerve dysfunction in pediatric leprosy patients. Hansen’s Trametinib cell line disease should be included in the differential diagnosis of asymmetric arthritis, especially in endemic regions. This study was supported by the Doutorado Inter Institucional (DINTER) of the Pediatric Department (UFMT-FMUSP), by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, under grant No. 302724/2011-7 to CAS), by a Federico Foundation grant to
CAS, and by the Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” of the Universidade de São (NAP-CriAd-SP). The authors declare no conflicts of interest. The authors would like to thank all the colleagues of the University Hospital of Cuiabá, Brazil, and Dr. Ulysses Dória Filho for assistance in statistical analysis. “
“Feeding Amino acid habits in the early phase of life plays a fundamental role in children’s growth and development;1 an appropriate introduction of solid foods is extremely important, as it can affect the future acceptance of
foods.2 Among the policies on food and nutrition, encouraging the consumption of fruits and vegetables stands out among the guidelines to promote healthy eating habits,3 and 4 since an insufficient consumption of these groups was considered one of the main factors responsible for the global burden of diseases worldwide.5 Preschoolers are characterized by having higher micronutrient requirements when compared to their energy needs.6 This aspect, combined with the evidence that their diets contain high levels of saturated fat and sugar and are low in dietary fiber,6 and 7 makes this age group vulnerable to the development of obesity and micronutrient deficiency.6 Furthermore, it has been demonstrated that children prefer foods with higher energy density, mainly by the positive physiological consequences that they provide in relation to satiety and energy input,8 which may affect the consumption of vegetables and fruits.