No record of fatality due to intussusception was found in the records for the defined review period. On an average 17.3 cases of confirmed intussusception were identified from this retrospective analysis. At CSMMU,

Lucknow atleast 14 cases per year were recorded over a duration of six years while at KMC, Manipal atleast 20 cases per year were recorded over a duration of five years. This analysis describes the epidemiological characteristics of intussusception in two regions of India. Epidemiology of intussusception in India is similar to that described in other parts of the world. Previous IWR-1 cell line reports specify that this condition is more frequent in males, with our study yielding a male to female ratio of 3.1:1. While the ratio varies widely across different countries, Quizartinib all reports indicated predominance of males. In the geographically close Asian region, studies report this ratio to range from 1.3:1 in Singapore [10] to 9:1 in India [11] and [12]. A possible trend, with highest cases reported in the month of April was observed. This is in contrast to reports

from other studies in which no such trend was reported [13], [14] and [15]. A peak of diagnosis (maximum number of cases) was observed in infants between 6 and 12 months of age. In this analysis, the classic triad of abdominal pain, vomiting, and rectal bleeding was reported in 18.7% of subjects which is higher than reported in a similar study conducted in India [14]. However, we found that clinical signs and symptoms in the present analysis were similar to those reported previously in other studies [14] and [15]. Vomiting was the most commonly recorded clinical symptom. We found that most of the cases were managed surgically which imposes a heavy economic burden on the health system in terms of prolonged hospital stay however this observation caries a potential bias as both the hospitals were tertiary care centers where relatively serious cases are

Mephenoxalone seen. The current study was limited by the lack of complete immunization data which made it difficult to reliably count the number and type of immunizations administered prior to hospitalization for intussusception. Additionally, the analysis was limited by the inability to define the catchment area for intussusception cases or to obtain accurate birth-cohort data for the catchment population. As data collected was from referral hospitals, these cases were those that were most severe and may not be representative of all cases identified through population surveillance This prevented the estimation of incidence of intussusception cases in a population. Nevertheless, the strength of this retrospective study is that it provides important insights into the epidemiology of intussusception among Indian children belonging to two different regions.