Biol Reprod 1997, 57: 847–55.CrossRefPubMed 9. Coy JF, Dressler D, Wilde J, Schubert P: Mutations in the Transketolase-like Gene TKTL1: Clinical Implications for Neurodegenerative this website Diseases, Diabetes and Cancer. Clin Lab 2005, 51: 257–73.PubMed 10. Di Chiro G, Hatazawa J, Katz DA, Rizzoli HV, De Michele DJ: Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and prob-ability of recurrence: a PET study. Radiology 1987, 164 (2) : 521–6.PubMed 11. Haberkorn U,
Strauss LG, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, Oberdorfer F, Rudat V, van Kaick G: Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med 1991, 32: 1548–55.PubMed
12. Comin-Anduix B, Boren J, Martinez S, Moro C, Centelles JJ, Trebukhina R, Petushok N, Lee WN, Boros LG, Cascante M: The effect of Selleckchem Ulixertinib thiamine supplementation on tumour proliferation. A metabolic control analysis www.selleckchem.com/products/ch5183284-debio-1347.html study. Eur J Biochem 2001, 268: 4177–82.CrossRefPubMed 13. Langbein S, Frederiks WM, zur Hausen A, Popa J, Lehmann J, Weiss C, Alken P, Coy JF: Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer. Int J Cancer 2008, 122: 2422–8.CrossRefPubMed 14. Hu LH, Yang JH, Zhang DT, Zhang S, Wang L, Cai PC: The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells. Anticancer Drugs 2007, 18: 427–33.CrossRefPubMed 15. Zhang S, Yang JH, Guo CK, Cai PC: Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett 2007, 253: 108–14.CrossRefPubMed 16. Zhang S, Yue JX, Yang JH, Cai PC, Kong WJ: Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma. Cancer Biology & Therapy 2008, 7: 517–22.CrossRef Competing interests
Morin Hydrate The authors declare that they have no competing interests. Authors’ contributions HC carried out the cell proliferation assay and drafted the manuscript. JXY participated in the design of the study and performed the statistical analysis. SHY carried out cell culture and plasmid construction. HD carried out transfection and RT-PCR. RWZ carried out measurements of transketolase activity. SZ conceived of the study, and participated in its design and coordination. All authors read and approved the final manuscript.”
“Introduction Cell cycle checkpoint functions regulate cell cycle progression and proliferation. Defects of cell cycle control are one among hallmarks of tumor development and may have relevance in tumor predisposition [1]. Cyclin-dependant kinase 4 (CDK4) is an important gene for cell cycle regulation, as it determines the number of cells entering the G1 phase cell cycle [2]. It is located on chromosome 12q14 and the protein encoded within this gene is a member of Ser/Thr protein kinase family.