“
“Background.— Persistent idiopathic facial

pain (PIFP) is defined as a persistent, unilateral facial pain, not associated with sensory loss or other physical signs and with no obvious structural abnormalities that would sufficiently explain pain experience. Objective.— We were interested whether there is evidence of altered brain morphology in patients with PIFP as it has been described in other chronic pain conditions. Methods.— Using voxel-based morphometry we investigated regional gray matter Poziotinib cost volume in 11 PIFP patients and 11 age- and sex-matched healthy controls. Furthermore we calculated lateralization indices (LI) to investigate differences in interhemispheric gray matter check details asymmetries. Results.— We report a decrease in gray matter volume in the left anterior cingulate gyrus and left temporo-insular region, as well as in the left and right sensory-motor area, projecting to the representational area of the face. Analyses of LI values demonstrated an increased rightward asymmetry in the middle-anterior insular cortex in patients in comparison with healthy controls. Conclusion.— Our data support previous findings showing that chronic pain states are display-altered

brain morphology in brain regions know to be part of the pain system. (Headache 2010;50:1278-1285) “
“There is little precedent for a medication-induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus Montelukast Sodium (FK506). A literature review for potential causes of a tacrolimus-induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use. “
“(Headache

2011;51:570-580) Objective.— Few prospective studies have evaluated the relationship between insomnia and headache. We aimed to analyze the influence of insomnia at baseline on the risk for headache 11 years later. Methods.— This longitudinal cohort study included subjects who participated in 2 consecutive surveys of the Nord-Trøndelag Health Study (HUNT-2 and HUNT-3). Among the invited individuals aged 20 years or more in HUNT-2 (n = 92,566) and HUNT-3 (n = 94,194), a total of 26,197 completed the headache section of both surveys. A proxy insomnia diagnosis based on DSM-IV at baseline and ICDH-2-based headache diagnoses at follow-up were derived from questionnaires. Headache-free individuals in HUNT-2 (n = 15,268) were selected for analysis. The relative risks (RRs) for headache in insomniacs were calculated with logistic regression. Results.