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“Background: Systemic coagulation disorders after cardiac surgery represent serious postoperative complications. There have been few reports, however, identifying preoperative coagulation tests that predict postoperative bleeding. The aim of the present study was to investigate the relationship between postoperative hemorrhage and coagulation parameters determined by global coagulation assays, to define potential predictive markers.
Methods: Twenty-one pediatric patients were enrolled. Blood samples Smoothened Agonist supplier were collected before and 24 h after cardiac surgery. Laboratory investigations included platelet count, hematocrit, classical coagulation tests [prothrombin time, activated partial thromboplastin time, thrombin-antithrombin complex (TAT)], rotation thromboelastometry (ROTEM), and the thrombin generation test (TGT). The duration of the
surgical procedure was recorded. Chest tube drainage was monitored for 24 h after operation as an index of postoperative hemorrhage.
Results: Comparisons between preoperative and postoperative results indicated that TAT increased significantly after operation, whereas ROTEM parameters did not show a hypercoagulable LB-100 nmr pattern. Preoperative endogenous thrombin potential (ETP) measured in the TGT and clot formation time (CFT) in the ROTEM correlated with chest tube drainage. The classical coagulation tests were not informative. Postoperatively, peak height and ETP in TGT, all ROTEM parameters, and duration of surgery were correlated with chest tube drainage. Duration of surgery was correlated with postoperative ROTEM parameters
but not with TGT. Postoperative maximum clot firmness and AUC were correlated with platelet count decrease ratio.
Conclusions: The preoperative CFT and ETP provide useful indices for predicting postoperative chest tube drainage volume. In addition, the duration of surgery also correlated with chest tube drainage and affected ROTEM parameters.”
“Here selective HDAC inhibitors we present a model that explains a number of the magnetic properties of arrays of cylindrical ferromagnetic nanowires. The model properly considers the magnetostatic contributions from the wire inhomogeneities, here taken as a chain of ellipsoidal grains, as well as the dipolar interactions summed in the overall array of hexagonal symmetry. Carrying out the complete sum of both the dipolar interactions between the ellipsoidal grains and between the nanowires, we obtain an analytical expression for the magnetostatic energy. The effective anisotropy field extracted from the magnetostatic energy predicts the change in the magnetization easy direction from parallel to perpendicular to the wire axis. The expressions contain information on microscopic parameters such as packing factor, length and diameter of the nanowires, and shape and size of the ellipsoids.