Cancer Chemother Pharmacol 2002, 50:479–489.XL184 concentration PubMedCrossRef 6. Long J, Manchandia T, Ban K, Gao JQEZ5 mouse S, Miller C, Chandra J: Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Cancer Chemother Pharmacol 2007, 59:527–535.PubMedCrossRef 7. Abraham NG, Kappas A: Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008,

60:79–127.PubMedCrossRef 8. Keyse SM, Tyrrell RM: Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci USA 1989, 86:99–103.PubMedCrossRef 9. Rushmore TH, Morton MR, Pickett CB: The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 1991, 266:11632–11639.PubMed 10. Nakaso K, Yano H, Fukuhara Y, Takeshima T, Wada-Isoe K, Nakashima K: PI3K is a key molecule in the Nrf2-mediated regulation

of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett 2003, 546:181–184.PubMedCrossRef RG7420 11. Wang L, Chen Y, Sternberg P, Cai J: Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest Ophthalmol Vis Sci 2008, 49:1671–1678.PubMedCrossRef 12. Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A: Regulation of heme Janus kinase (JAK) oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt

pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 2004, 279:8919–8929.PubMedCrossRef 13. Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD: Dual roles of Nrf2 in cancer. Pharmacol Res 2008, 58:262–270.PubMedCrossRef 14. Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, Biswal S: RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 2008, 68:7975–7984.PubMedCrossRef 15. Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008, 29:1235–1243.PubMedCrossRef 16. Barnes DJ, De S, van Hensbergen P, Moravcsik E, Melo JV: Different target range and cytotoxic specificity of adaphostin and 17-allylamino-17-demethoxygeldanamycin in imatinib-resistant and sensitive cell lines. Leukemia 2007, 21:421–426.PubMedCrossRef 17.