Despite these limitations, this meta-analysis suggests that the XRCC3 Thr241Met polymorphisms are not associated with lung GW786034 manufacturer cancer risk stratified analysis by ethnicity, histology and smoking status. However, it is necessary to conduct large sample studies using standardized unbiased genotyping methods and well-matched controls. Acknowledgments This work was supported in part by a grant from “Twelve-Five Plan” the Major Program of Nanjing Medical Science and Technique Development Foundation

(Molecular Mechanism Study on Metastasis and Clinical Efficacy Prediction of Non-small Cell Lung Cancer) (Lk-Yu) and Third Level Training Program of Young Talent Project of Nanjing Health (P-Zhan) References click here 1. Alberg AJ, Samet JM: Epidemiology of lung cancer. Chest 2003, 123:21–49.CrossRef 2. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA: Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008, 83:584–594.PubMed 3. Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, Hsu AA, Eng P, Koong HN, Thirugnanam A, Tan EH: Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol 2006, 24:2245–2251.PubMedCrossRef 4. Benhamou S, Sarasin A: ERCC2/XPD gene polymorphisms and lung cancer: a HuGE review. Am J Epidemiol 2005, 161:1–14.PubMedCrossRef

5. Spitz MR, Wu X, Wang Y, Wang LE, Shete S, et al.: Modulation of nucleotide excision repair capacity Arachidonate 15-lipoxygenase by XPD polymorphisms in lung cancer patients. Cancer Res 2001, 61:1354–1357.PubMed GM6001 molecular weight 6. Zhan P, Wang Q, Wei SZ, Wang J, Qian Q, Yu LK, Song Y: ERCC2/XPD

Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case–control studies. J Thorac Oncol 2010,5(9):1337–1345.PubMedCrossRef 7. Ji YN, Zhan P, Wang J, Qiu LX, Yu LK: APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis. Mol Biol Rep 2011,38(7):4537–4543.PubMedCrossRef 8. Tebbs RS, Zhao Y, Tucker JD, et al.: Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci USA 1995, 92:6354–6358.PubMedCrossRef 9. Lee JM, Lee YC, Yang SY, Yang PW, Luh SP, Lee CJ, Chen CJ, Wu MT: Genetic polymorphisms of XRCC1 and risk of the esophageal cancer. Int J Cancer 2001, 95:240–246.PubMedCrossRef 10. Matullo G, Palli D, Peluso M, Guarrera S, Carturan S, Cementano E, Krogh V, Munnia A, Tumino R, Polidoro S, Piazza A, Vineis P: XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects. Carcinogenesis 2001, 22:1437–1445.PubMedCrossRef 11. Cochran WG: The combination of estimates from different experiments. Biometrics 1954, 10:101–129.CrossRef 12.