Diabetes 54(2):563–569PubMedCrossRef 8. Hallal PC et al (2009) The role of early life variables on the risk of fractures from birth to early adolescence: a prospective birth cohort study. Osteoporos Int 20(11):1873–1879PubMedCrossRef 9. Hui SL, Slemenda CW, Johnston CC Jr (1990) The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int 1(1):30–34PubMedCrossRef 10. Kelly PJ et al (1995) Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol 133(3):265–271PubMedCrossRef 11. Lorentzon M, Mellstrom D, Ohlsson
C (2005) Age of attainment of peak bone mass is site specific in Swedish men—a GOOD study. J Bone Miner Res 20(7):1223–1227PubMedCrossRef
12. Poole KE, Compston JE (2006) Osteoporosis and its management. BMJ 333(7581):1251–1256PubMedCrossRef MM-102 order 13. Rizzoli R, Bonjour JP (1999) Determinants of peak bone mass and mechanisms Pictilisib of bone loss. Osteoporos Int 9(Suppl 2):S17–S23PubMedCrossRef 14. Statistics Sweden, Socioeconomic Classification (SEI). 1982, Statistics Sweden: Stockholm. 15. Seeman E et al (1989) Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320(9):554–558PubMedCrossRef 16. Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726–1733PubMedCrossRef 17. Clark EM, Ness A, Tobias JH (2005) Social position affects bone mass in childhood through opposing actions
on height and weight. J Bone Miner Res 20(12):2082–2089PubMedCrossRef 18. Cooper C et al (2001) Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporos Int 12(8):623–629PubMedCrossRef 19. Tough SC et al (2002) Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery. Pediatrics 109(3):399–403PubMedCrossRef 20. Antoniades L et al (2003) Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatol Oxf 42(6):791–796CrossRef 21. Junien C, Nathanielsz P (2007) Report Amobarbital on the IASO Stock Conference 2006: early and www.selleckchem.com/products/GSK461364.html lifelong environmental epigenomic programming of metabolic syndrome, obesity and type II diabetes. Obes Rev 8(6):487–502PubMedCrossRef”
“Introduction The pharmacological armamentarium for the management of osteoporosis has considerably expanded. Indeed, ability to substantially reduce fracture risk with a generally favourable risk–benefit ratio is now documented in well-conducted large clinical trials for a series of different molecules encompassing different pharmacological classes and different modes of action [1]. Osteoporosis is a highly prevalent problem in the ageing population, and the absolute number of affected subjects increases as a consequence of demographic evolutions.