Lifelong antifungal therapy following surgical intervention has been discussed in studies, because of the potential for recurrent

infections after Aspergillus endocarditis, which arise from residual cardiac foci and metastatic lesions. The risk of recurrent fungal endocarditis in survivors was 30% in a study which analysed cases of fungal endocarditis from 1965 to 1995.[64] A case report from 2013 demonstrates that surgery www.selleckchem.com/products/LDE225(NVP-LDE225).html is also necessary in case of intracardial Aspergillus vegetations. Cardiopulmonary bypass is required to be able to perform open-heart surgery, which allows removal of vegetations and exploration of the endocardium, to detect possible further invasion of the infection. Aspergillus endocarditis patients are mostly immunocompromised and this kind of major surgery is putting them under additional stress, however, the risk of fatal embolisation may be higher than the risk of the procedure. In case of Aspergillus vegetations growing on the surface of pacemaker wire, surgery is indicated as well. For removal ether intravascular retraction methods or thoracotomy are performed. However, if the vegetations are larger than 1 cm, the risk of fatal embolic events during retraction is too high so that thoracotomy should be preferred.[61] Extensive surgery and complete recovery was reported by Reis et al. [63] in a

case report from 2005. The patient received an aortic Roxadustat root bioprosthesis after bacterial endocarditis, however, about 3 months after surgery he developed postoperative endocarditis due to Aspergillus, manifesting Protein Tyrosine Kinase inhibitor in several severe embolic events and peri-root abscess with extension of infected material to the aortic wall. He repeatedly received aortic root replacement with a cryopreserved homograft. A third aortic root replacement would have been indicated

after recurrent embolism and dehiscence of the aortic homograft from its left ventricular outflow tract, as well as a new right atrial vegetation but the patient refused surgery and surprisingly recovered under systemic oral antifungal therapy. A recent review of 53 published cases of Aspergillus endocarditis by Kalokhe et al. [60] found that only 4% (2/53 cases) were treated successfully with antifungal therapy alone, indicating surgical debridement as imperative for the survival of Aspergillus endocarditis. However, the outcome was still very poor with only 17 of 53 reported cases (32%) surviving the acute episode of Aspergillus endocarditis. One case was reported, in which surgical extraction of a pacemaker wire was necessary due to Aspergillus vegetation. Intraoperatively, it was noted that the endocardial Aspergillus vegetation had invaded the right atrium, tricuspid valve, intra-atrial septum and superior vena cava requiring extensive debridement. In a study by Mc Cormack et al.