Specifically, variation of CrCP following visual stimulation was progressively reduced, more than a half, during orthostatic challenge. Opposed to this pattern, RAP and CVRi seemed to decrease slightly more during HUT. From the changes in CVRi, one would assume that despite rising baseline resting values with seating and HUT, the correspondingly

larger decreases with orthostasis during NVC activation (Table 1) would simply reflect arteriolar vasodilation to match the increased demand for O2. The problems with the single-parameter model of CVR are two-fold. First, it has been demonstrated that instantaneous pressure–velocity relationships of the cerebral circulation do not tend to intercept the pressure axis at the origin [20] and [22]. Second, CVRi cannot explain the complexities of the interplay

between NVC and dynamic cerebral autoregulation [32]. This complexity can be appreciated by the buy 17-AAG this website changes in CrCP and RAP. Although the temporal response of RAP (Fig. 1) was not significantly different for the three body positions considered, overall it tends to reflect the myogenic response of dynamic autoregulation, mainly as a compensation for the drop in ABP following neural stimulation (Fig. 1E). It is likely that some of its change also contributed to the rise in CBV during the response (Fig. 1A). On the other hand, it can be speculated that the changes in CrCP are mainly reflecting the action of metabolic mechanisms [22] and [33]. If this is the case, then it is not possible to say that the NVC response to reading is entirely indifferent to orthostasis, since reading and HUT seem to require less metabolic-coupled changes than responses in the supine position. Some studies have oxyclozanide shown significant [30], [35], [36] and [37] or no statistically

significant [38] increases in ABP and HR during mental activation. Moody et al. [30] analysed the hemodynamic changes of cerebral and systemic responses, putting into evidence an initial ABP peak, ∼5 s after MCA cortical activation, that would drive an early-phase cerebral vasoconstriction reflected in increased CVRi and RAP, followed by metabolic vasodilatation. Our results showed non-significant changes in HR and ABP responses. A watchful eye through the curves of ABP in Fig. 1E might identify an initial ABP peak at ∼5 s only at sitting condition. Also, the previously described possible initial ‘vasoconstriction response’ [30] could not be demonstrated. With the same as ours activation paradigm, Rosengarten et al. [37] found no relevance of HR effects in regulative features of the activity–flow coupling during reading task. A possible explanation to discrepant findings between the studies can be a less demanding visual paradigm related to the PCA territory as compared to MCA-activation paradigm, rendering a less pronounced systemic/sympathetic response.