Table 2 The results and correlation of TEG® and ROTEM® parameters

in each study for diagnosis, transfusion guidance and prognosis Diagnosis                 TEG ® Test Study r /ACT k α A MA CL G Comments   TEG® Schreiber (2005) PTT       Platelet           Johansson (2008b)               r, k, α, MA and G improved after Tx packages     Plotkin (2008)         Platelet           Park (2009)     NO correlation Selonsertib mouse to PT/PTT   NO correlation to PT/PTT           Watters (2010)               MA significantly higher post-splenectomy   TEG®-PM Nekludov (2007)               Reduced platelet response to AA in bleeders   Rapid-TEG® Jeger (2009)   Platelet/INR Platelet/INR   Platelet/INR           Cotton (2011) PT/PTT PT/PTT PT/PTT/platelet   PT/PTT/platelet   No correlation   ROTEM ® Test Study CT CFT

α CA MCF CLI ML     EXTEM® Rugeri (2006)       PT (CA15)             Levrat (2008)       ELT (CA10) ELT ELT (CLI60)         Davenport (2011a)               CT, CA, MCF improves after Tx     Davenport (2011b)               CA5 diagnosis coagulopathy   INTEM® Rugeri (2006)   PTT   PTT / Platelet (CA15)           FIBTEM® Rugeri (2006)       Fibrinogen (CA10)         Transfusion Guidance                 TEG ® Test Study r / ACT k α A MA CL G Comments   Rapid-TEG® Kashuk (2009) Could reduces FFP Tx               ROTEM ® Test Study CT CFT α CA MCF CLI ML     EXTEM® Schochl (2011) Repotrectinib               ROTEM guided FC/PCC reduces RBC and platelet Tx   FIBTEM® Schochl (2011)               ROTEM guided FC/PCC reduces RBC and platelet

Tx Prognosis                 TEG ® Test Study r / ACT k α A MA CL G Comments   TEG® Plotkin (2008)         Increased Tx           Park (2008)         Mortality           Johansson (2008a)               TEG guided Tx reduced mortality     Carroll (2009) Mortality       Mortality         TEG®-PM Carroll (2009)               Significantly correlated to Tx   Rapid-TEG® Glutathione peroxidase Kashuk (2010)             Mortality       Kashuk (2012)           Mortality Mortality       Pezold (2012)             Massive Tx; Mortality   ROTEM ® Test Study CT CFT α CA MCF CLI ML     EXTEM® Schochl (2009)             Mortality       Doran (2010)         Increased Tx           Schochl (2010)               ROTEM guided Tx reduces mortality   INTEM® Leemann (2010)         Increased Tx       Abbreviations: r, k, α and MA – TEG® parameters; CT,CFT, α, MCF, CA10, CA15, CL30-CL60 – ROTEM® parameters; ACT – activated clotting time; ELT – euglobulin lysis time; FFP – fresh frozen plasma; G – Saracatinib in vitro maximal elastic modulus (d/sc); PC – platelet concentrate; PCC – prothrombin complex concentrate; Tx – transfusion Results of 12 studies on the use of TEG® or ROTEM® as diagnostics tools Among the studies on TEG® Schreiber et al reported a correlation between r and PTT, and between MA and platelet count [13].