The affinity between

the hydrophilic inert carriers of the dissolution fluids facilitates rapid penetration into the particles, which further enhances the dissolution CH5424802 in vitro process. The dissolution rate for all SD are in the order of crospovidone > sodium starch glycolate > microcrystalline cellulose > croscarmellose > potato starch. The surface solid dispersion technique has been shown as a successful approach to improve the dissolution rate of irbesartan. The nature and the amount of carrier used, played an important role in the enhancement of the dissolution rate. The spectral studies showed no interaction of irbesartan with polymer. Among the super disintegrants tested, CP gave highest enhancement of dissolution rate and efficiency of with irbesartan 1:10 ratio. In each case the dissolution rate was increased as the concentration of carriers in the surface solid dispersions was increased. This method could be incorporated successfully, into a tablet by conservative wet granulation technique. All authors have none to declare. The authors are thankful to Dr. Reddy’s laboratories, Hyderabad, Andhra Pradesh, India for providing gift sample of Irbesartan.

One of the authors (G Bhagavanth Reddy) would like to thank CSIR, New Delhi for the award of Senior Research Fellowship. “
“The spread of multidrug resistant pathogens MLN2238 purchase is one of the severe threats to mankind in recent years. Drug resistance has become serious problem especially heptaminol due to the frequent use of antibiotics in massive quantities. In recent years, silver nanoparticles (AgNPs) with zero, one, or two-dimensional nanostructures such as nanoparticles, nanowires, and nanocubes have been the subject of focused research due to their great biocidal potential.1, 2, 3 and 4 Many techniques are known to be available with the evidence of publication for the synthesis of AgNPs, such as chemical reduction of silver ions with or without stabilizing agents,5 thermal decomposition,6 chemical reduction and photoreduction,7

radiation chemical reduction etc.8 But these methods are very expensive and involve the use of non ecofriendly toxic chemicals. Thus there is a growing need to develop environmental friendly processes for synthesis of nanoparticles that do not use toxic chemicals. Biological methods of nanoparticle synthesis using microorganisms,9, 10 and 11 enzymes,12 fungus,13 and plants or plant extracts have been suggested in many literature as possible ecofriendly alternative to chemical and physical methods.14 But no report available showing the comparison of antimicrobial effect of chemically synthesized AgNPs, with that are synthesized by plant extract against MDR bacterial isolates to draw more attention towards extensive research on green synthesis of AgNPs.