23 The association between CMV infection and acute coronary syndromes has also been investigated. Kol et al. investigated the presence of CMV in atherectomy specimens from patients with stable versus unstable angina using southern blotting and hybridization with a specific probe for detecting the CMV major immediate-early (MIE) gene.24 They found no specimen with a positive hybridization signal and concluded that in patients with unstable angina, replication of CMV in coronary Inhibitors,research,lifescience,medical atherosclerotic plaques is not a major cause of plaque instability. However, Liu et al.25 investigated the presence of CMV in the coronary plaques of 23 patients
with coronary syndromes and compared them with 17 control patients using immunohistochemical techniques; they found a significantly higher rate of infection in the acute coronary syndrome group (P=0.01). In our study, using a more sensitive PCR method, we found Inhibitors,research,lifescience,medical the same results as the latter study in which patients who had positive PCR results for CMV DNA were significantly more likely to have a history of unstable angina or myocardial infarction.
This finding is of utmost relevance: not only does it show a high rate of CMV infection Inhibitors,research,lifescience,medical present in atherosclerotic plaques, but it also confirms through clinical evidence a higher risk of acute coronary syndromes for CMV replication in atherosclerotic plaques. This in turn should encourage us to find preventive strategies toward a potential favorable effect of using antiviral agents to prevent ominous heart events. A novel finding of this study is the association between a positive CMV DNA detection in the atherosclerotic Inhibitors,research,lifescience,medical plaques and a positive family history for CVD. As mentioned above, autopsy analysis of young people who died from trauma revealed positive CMV DNA in their coronary artery specimens, with no clinical evidence of CVD. Some investigators suggested that this finding implies a role for CMV infection in initiating the atherosclerosis process in the coronary arteries.
However, we suggest that the higher rate of a positive family Inhibitors,research,lifescience,medical history of CVD for patients with CMV-positive atherosclerosis implies that their arterial walls have a higher sensitivity to CMV replication. This implication is also very LY294002 cell line relevant because, if proven, one may assume that such Bumetanide family members should begin preventive antiviral treatment. CMV infection has also been associated with arterial hypertension,26 diabetes mellitus-mediated atherosclerosis,27 and a positive test for proliferative signals including CRP.13 In our current study, we did not find any relationship between CMV IgM, CMV IgG, and CMV PCR positivity and having arterial hypertension or higher systolic and/or diastolic blood pressure (data not shown). Moreover, no association was found with regard to diabetes mellitus and any of the CMV tests. The same observation was found when CMV test results were correlated with CRP.