Deterioration of renal function was observed in only one patient, which was deemed to be due to diabetes mellitus. The limitation of the present study is the relatively

small sample Alectinib order size and short follow up. This was predominantly due to the limited enrollment period and stringent criteria for enrollment. Moreover, due to a lack of resources, standardized pads were not used to quantify the degree of incontinence. Nevertheless, it presents a comprehensive clinico-urodynamic analysis of lower urinary tract function in patients with orthotopic neobladder and incites researchers for larger and longitudinal studies on urethral function evaluation in this patient-group using urethral pressure profilometry. To conclude, in patients undergoing cystoprostatectomy, Birinapant cost W-configured detubularized ileal neobladder with extramural serosal-tunnel non-refluxing uretero-ileal anastomosis has acceptable functional characteristics in terms of good capacity, compliance, absence of reflux and ability to empty without having to resort to CIC. However, A significant proportion of patients do have urinary incontinence (night > day) impacting quality of life. Regular pelvic floor muscle training consisting of strengthening and relaxation exercises may help improve lower urinary tract function. There is no conflict

of interest to disclose by any author. S. no Questions 1 2 3 4 5 Evacuation of urine             1 Way of evacuation of urine Voluntary Only by self catheterization Voluntary voiding followed by CIC On perurethral catheter   2 Subjective voiding time Normal Slightly prolonged Moderately

prolonged Much prolonged   3 Voiding posture Sitting Standing Squatting     4 Hesitancy on voiding None < 10 sec 10–30 sec 30–60 sec > 1 min 5 Intermittency on voiding None Only at end of voiding Only at Initiation Throughout voiding   6 Abdominal straining None Only at end of voiding Only at Initiation Throughout voiding   7 Degree of abdominal Bay 11-7085 straining None Mild Moderate Excessive   8 Crede’s maneuver None Occasionally Performed Always performed     9 Sense of residual urine Absent Occasionally present Always present     10 Force of urine stream Excellent Good Weak Poor Dribbling 11 Voiding compared to preoperative status Excellent Slightly better Same Slightly poor Worse Storage of urine             12 Frequency of micturition 1 2 3 4 5 13 Sense of desire to void None Abdominal fullness Sense of urinary leak Pain   14 Presence of incontinence Absent Present       15 Type of incontinence None With urge With stress Continuous On prolong retention 16 Frequency of Incontinence None Day only Night only Both day and night   17 Grade of day time incontinence None A few drops Underwear wetting Cloths wetting   18 Grade of night time incontinence None A few drops Underwear wetting Cloth wetting Bed wetting 19 Wearing of pad during day time None Occasionally Always for protection Always   20 No.