“In this study, we isolated a new glucoside of the resveratrol trimer
(hopeaside E) from the stem wood of Hopea utilis. The glucoside structure is partially composed of balanocarpol (resveratrol dimer) after oxidative condensation of the (E)-resveratrol-10-C-beta-glucopyranoside. The structure elucidation was achieved by spectroscopic analysis including NMR experiments, and the absolute configuration histone deacetylase activity was determined on the basis of the comparative configurational analysis with the beta-D-glucopyranosyl group. Conformational analysis was also performed by considering deshielding effects due to aromatic rings using computational methods of molecular modeling. The aglycone has six asymmetric carbons with two
aliphatic hydroxyl groups attached to them that has not been reported in any other resveratrol derivative studies. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Background/Aims. Vitamin D(3) is liposoluble, so dietary fat could increase its oral absorption. Our aim was to compare serum 25-hydroxyvitamin D [25(OH) D] after the oral intake of cholecalciferol with a high-or low-fat meal. Methods. In a single-blind, parallel clinical trial, 32 healthy physicians were divided into two groups. In the same day, they ingested 50,000 IU (1.25mg) of vitamin D3 with food: group 1 (G1): lipids: 25.6 g and group 2 (G2) lipids: 1.7 g. Serum 25(OH) D (0, 7, and 14 days), LY3039478 Stem Cells & Wnt inhibitor and parathyroid hormone (PTH), and calcium (0 and 14 days) were measured. Results. Baseline mean serum 25(OH) D levels were 42.7 +/- 19.0 nmol/L in G1 and 36.4 +/- 19.0 nmol/L in G2 (P = 0.38). After cholecalciferol, mean serum 25(OH) D was higher in G1 (P < 0.001): 7 days: G1 = 46.2 (38.4-53.9)
nmol/L and G2 = 33.7 (25.4-40.1) nmol/L; 14 days: G1 Fer-1 = 53.7 (45.2-62.1) nmol/L and G2 = 33.7 (25.2-42.2) nmol/L. Serum PTH and 25(OH) D were negatively correlated before and after the intake of vitamin D(3), respectively, r = -0.42 (P = 0.02) and r = -0.52 (P = 0.003). Conclusions. A high-fat meal increased the absorption of vitamin D3, as measured by serum 25(OH) D.”
“Two new acylated dolabellane-type diterpenes, nigellamines B-3 (9) and D (10), were isolated from Nigella sativa (Ranunculaceae) seeds using column chromatography and preparative HPLC. Their structures were determined based on chemical and physicochemical evidence, and confirmed using previously isolated related compounds as reference. Of the seed constituents, nigellamines A(2) (2), A(3) (3), A(5) (5), B-1 (6), and B-2 (7) had in vitro triglyceride metabolism-promoting activities in the high glucose-pretreated human liver carcinoma cell line, HepG2. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V.