The Quisinostat research buy following ‘risk indices’ were significantly ‘deleterious’: plasma creatinine (kidney function),

plasma alkaline phosphatase (marginally significant: bone health), plasma α1-antichymotrypsin (acute phase status). Notably, plasma calcium was not a KU55933 significant predictor, and it remained so after adjustment for plasma albumin [12] (not shown). Table 3 Age-adjusted hazard ratios for the anthropometric, biochemical and nutritional indices for all-cause mortality, showing both sexes combined, and each sex separately   Age-adjusted all-cause mortality: hazard ratios (95% CI) [P] Both sexes combined Men Women Died (n = 717), alive (n = 337) Died (n = 399), alive (n = 139)a Died (n = 318), alive (n = 198)a Indices (per SD)  Body weight 0.84 (0.77–0.93) [<0.001] 0.84 (0.74–0.95) Regorafenib supplier [0.005] 0.85 (0.74–0.97) [0.02]  Body mass index (BMI) 0.90 (0.83–0.98) [0.02] 0.90 (0.79–1.03) [0.1] 0.90 (0.81–1.01) [0.07]  Waist circumference 0.99 (0.99–1.08) [0.9] 0.95 (0.85–1.07) [0.4] 1.04 (0.92–1.17) [0.6]  Mid-upper arm circumference

0.85 (0.77–0.93) [<0.001] 0.86 (0.76–0.99) [0.03] 0.83(0.74–0.95) [0.005]  Grip strength 0.79 (0.71–0.88) [<0.001] 0.72 (0.64–0.82) [<0.001] 0.97 (0.80–1.17) [0.8]  Plasma calcium (mmol/l) 0.96 (0.88–1.05) [0.3] 0.99 (0.88–1.12) [0.9] 0.92 (0.81–1.05) [0.2]  Plasma phosphorus (P) (mmol/l) 1.13 (1.04–1.23) [0.004] 1.18 (1.06–1.30) [<0.001] 1.04 (0.91–1.20) [0.5]   Plasma P adj. for plasma α1-antichymotrypsin 1.09 (1.00–1.18) [0.04] 1.10 (1.00–1.21) [0.05] –  Plasma 25OHD (nmol/l) 0.89 (0.82–0.98) [0.01] 0.91 (0.82–1.02) [0.1] 0.87 (0.75–1.00) [0.06]  Plasma parathyroid hormone (ng/l) 1.03 (0.93–1.15) [0.5] 1.03 (0.88–1.21) [0.7] 1.05 (0.91–1.21) [0.5]

 Plasma alkaline phosphatase(IU/l) 1.08 (1.01–1.15) [0.02] 1.06 (0.89–1.26) [0.5] 1.08 (1.01–1.16) [0.03]  Plasma creatinine (μmol/l) 1.24 (1.13–1.35) [<0.001] 1.20 (1.08–1.33) [<0.001] 1.37 (1.13–1.66) Resminostat [<0.001]  Plasma albumin (g/l) 0.83 (0.76–0.91) [<0.001] 0.84 (0.74–0.94) [0.004] 0.83 (0.72–0.96) [0.01]  Plasma α1-antichymotrypsin (g/l) 1.22 (1.14–1.32) [<0.001] 1.21 (1.11–1.33) [<0.001] 1.27 (1.11–1.45) [<0.001] Daily dietary intakes (per SD)  Energy 0.86 (0.79–0.94) [0.001] 0.85 (0.76–0.95) [0.003] 0.90 (0.77–1.05) [0.2]  Calcium 0.88 (0.81–0.95) [0.002] 0.88 (0.79–0.98) [0.02] 0.89 (0.78–1.01) [0.07]   Calcium adjusted for diet energy 0.93 (0.84–1.03) [0.2] 0.96 (0.84–1.10) [0.6]    Phosphorus 0.85 (0.78–0.92) [<0.001] 0.87 (0.78–0.96) [0.005] 0.82 (0.72–0.95) [0.007]   Phosphorus adjusted for diet energy 0.88 (0.78–0.98) [0.02] 0.93 (0.81–1.07) [0.3] 0.79 (0.86–0.95) [0.01]  Vitamin D 0.94 (0.88–1.01) [0.1] 0.90 (0.82–0.99) [0.03] 1.03 (0.91–1.16) [0.