Simple regression analysis revealed that the volumetric selleck compound proportion of each plaque type correlated significantly with the corresponding plaque-type area at the minimum lumen site. The adjusted coefficients of determination of the simple regression analyses were .782 (P < .001) for fibrous tissue, .741 (P < .001) for fibrofatty tissue, .864 (P < .001) for dense calcium, and .918 (P < .001) for necrotic core. The plaque composition at the minimum lumen site represents the volumetric composition of the entire carotid plaque that causes atherosclerotic cervical carotid artery stenosis. "
“Diffusion tensor imaging (DTI) quantifies the motion of water

within brain tissue. Inflammation leads to tissue disruption, resulting in increased diffusivity and decreased directionality. We aimed to quantify the damage within tumefactive giant brain lesions

(TGL) in multiple sclerosis (MS) using MRI and DTI methodology. Region of interest were determined on TGL and acute MS lesions to obtain metrics such as volume, apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (λ||), and radial diffusivity (λ⊥). We identified 10 TGL in 10 patients with MS. The incidence of TGL was 2.8%. Comparing TGL to acute 16 MS lesions, DTI metrics demonstrated significantly higher ADC, λ|| and λ⊥ diffusivities and lower FA values in TGL (P <.001). Five TGL were reevaluated after buy R788 120 days by MRI and DTI metrics. Significant group changes were detected at 120 days: TGL volume decreased, ADC, λ|| and λ⊥ values were lower and FA was higher

(P < .01). Within the spectrum of acute MS lesions, TGL present DTI metrics of an intense acute inflammatory process. Analysis of TGL progression proposes that DTI metrics sensitively detects micro-structural changes in TGL from acute inflammation towards lesion recovery and reorganization. "
“To prospectively evaluate longitudinal changes in white matter lesions (WMLs) in migraineurs with aura, by magnetic resonance imaging (MRI), and to correlate WMLs modifications with patients’ clinical characteristics. Forty-one consecutive migraineurs with aura were followed for a mean time of 33.2 months. 上海皓元 Patients underwent MRI at baseline and follow-up and were evaluated for cerebrovascular risk factors. Presence of WMLs on MRI was assessed by two neuroradiologists. WMLs were present in 26 subjects (63.4%) at baseline MRI. At follow-up a total of 8 patients had new WMLs (19.5%). There was a significant correlation between aura duration and number of new WMLs, and between the number of migraine attacks with aura and new WMLs. Our study demonstrates that in migraine with aura WMLs number can progress over time and suggests an association between aura features and WMLs progression. Studies with a higher number of patients are required to confirm these findings. “
“Recent advancement for magnetic resonance imaging (MRI) involves the incorporation of higher-field strengths.