The implications

of differential

The implications

of differential MEK162 order access to oral bisphosphonates warrants further study. Acknowledgements This GF120918 concentration Research was supported by research grants from the Canadian Institutes of Health Research (CIHR, DSA-10353) and the Ontario Ministry of Research and Innovation (OMRI, Early Researcher Award). Ms Beak was supported by a CIHR Health Professional Student Research Award, and Drs Cadarette (Aging and Osteoporosis) and Dormuth (Knowledge Translation) hold CIHR New Investigator Awards. Authors acknowledge Brogan Inc. for providing access to drug identification numbers used to identify eligible drugs. The Institute for Clinical Evaluative Sciences (ICES) is a nonprofit research corporation funded Tariquidar by the Ontario Ministry of Health and Long-Term Care. The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by CIHR, ICES, OMRI, or the Ontario Ministry of Health and Long-Term Care is intended or should be inferred. Conflicts of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution,

and reproduction in any medium, provided the original author(s) and source are credited. References 1. Papaioannou A, Morin S, Cheung AM et al (2010) 2010 clinical practice guidelines for the diagnosis and management of Arachidonate 15-lipoxygenase osteoporosis in Canada: summary. Can Med Assoc J 182:1864–1873CrossRef 2. MacLean C, Newberry S, Maglione M et al (2008) Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med 148:197–213PubMed 3. Cranney A, Guyatt G, Griffith L et al (2002) IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev 23:570–578PubMedCrossRef 4. Osteoporosis Canada Provincial Drug Coverage Chart. http://​www.​osteoporosis.​ca/​index.​php/​ci_​id/​9046/​la_​id.​htm. Accessed

11 Jan 2011 5. Ontario Ministry of Health and Long-Term Care Formulary Search: Ontario Drug Benefit Formulary/Comparative Drug Index. https://​www.​healthinfo.​moh.​gov.​on.​ca/​formulary/​index.​jsp. Accessed 11 Jan 2011 6. Cadarette SM, Jaglal SB, Raman-Wilms L, Beaton DE, Paterson JM (2011) Osteoporosis quality indicators using healthcare utilization data. Osteoporos Int 22:1335–1342PubMedCrossRef 7. Brown JP, Josse RG, Scientific Advisory Council of the Osteoporosis Society of Canada (2002) 2002 Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. Can Med Assoc J 167(10 Suppl):S1–S34 8. Brown JP, Fortier M, Frame H et al (2006) Canadian consensus conference on osteoporosis, 2006 update. J Obstet Gynaecol Can 28:S95–S112PubMed 9.

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