These major achievements will be discussed in this review keeping in mind newcomers, young, and established scientists in proteomics and plants.”
“Monitoring molecular dynamics of an organism upon stress is probably the best approach to decipher physiological mechanisms involved in the stress

response. Quantitative analysis of proteins and metabolites is able to provide accurate information about molecular changes allowing the establishment of a range of more or less specific mechanisms, leading to the identification of major players in the considered pathways. Such tools have been successfully used to analyze the plant response to cadmium (Cd), a major pollutant capable of causing severe health issues as it accumulates in the food chain. We present a summary of proteomics and metabolomics works that contributed AZD3965 to a better understanding of the molecular aspects buy Trichostatin A involved

in the plant response to Cd. This work allowed us to provide a finer picture of general signaling, regulatory and metabolic pathways that appeared to be affected upon Cd stress. In particular, we conclude on the advantage of employing different approaches of global proteome- and metabolome-wide techniques, combined with more targeted analysis to answer molecular questions and unravel biological networks. Finally, we propose possible directions and methodologies for future prospectives in this field, as many aspects of the plant-Cd interaction remain to be discovered.”
“Retinitis pigmentosa (RP) is a group of inherited degenerative eye diseases MK-2206 supplier characterized by mutations in the genetic structure of the photoreceptors that leads to the premature death of both rod and

cone photoreceptors. Defects in particular genes encoding proteins that are involved in either the photoreceptor structure, phototransduction cascades, or visual cycle are expressed in the rods but ultimately affect both types of cells. RP is “”typically”" manifested by a steady death of rods followed by a period of stability in which cones survive initially and then inevitably die too. In some RP cases, rods and cones die off simultaneously or even cone death precedes rod death (reverse RP). The mechanisms and factors involved in the development of the different types of RP are not well understood nor have researchers been able to provide more than a limited number of short-term therapies. In this work we trace the progression of RP to complete blindness through each subtype via bifurcation theory. We show that the evolution of RP from one stage to another often requires the failure of multiple components. Our results indicate that a delicate balance between the availability of nutrients and the rates of shedding and renewal of photoreceptors is needed at every stage of RP to halt its progression.