Methods: HK Chinese and UK Caucasian patients with CEAP clinical grade 4-6 venous disease were enrolled. Patients with conditions known to be associated with thrombophilia (TP) were excluded. UK and HK patients were matched by gender, age (within 5 years) and by CEAP clinical grade. All subjects underwent clinical examination, venous duplex ultrasound, and measurement of Hcy and factors (F) VIII, IX and XI.

Results: 63 Patients were enrolled

in each group: Mean age 64y (HK group); 67y (UK group). 37% were female; 19% had active venous ulceration. One-third of patients in each group had deep venous reflux. High Hcy, FIX and FXI were significantly more common in the UK group. Multiple TP was more common in the UK group: raised levels of >= 2 factors in 26 vs. 14 patients (P = 0.022, x(2)). Median Hcy (14.3 vs. 10.8 mu mol/L; P < 0.0005, Ipatasertib Wilcoxon signed rank [WSR]), FIX (131 vs. 115%; P = 0.048), and FXI (114 vs. 97%; P = 0.002) were significantly higher in the UK group. There was no significant difference in FVIII levels.

Conclusions: Raised procoagulant factors were more common in Caucasians compared with Chinese patients with CVI in this study. As with the inherited thrombophilias, the pattern of raised procoagulant factors in Chinese patients appears to differ from that in Caucasians. (C) 2010 European Society for Vascular

Surgery. Published by Elsevier Ltd. All rights reserved.”
“Objective: To evaluate sensitivity and validity of the Danish Selleck Sapanisertib National Patient Registry (NPR) including relevant International Classification of Diseases, Eighth Revision (ICD-8) and

International Classification of Diseases, Tenth Revision (ICD-10) codes and explore potential benefits of combining diagnosis and department codes in composite search strategies.

Study Design and Setting: The study click here period was 1985-2004. Medical records of patients identified with one or more of seven ICD-8 or ICD-10 codes from a number of registries were reviewed to confirm or reject the craniopharyngioma diagnosis. NPR sensitivity was evaluated in North Jutland County through comparison with hospital registries, the county registry, and the Danish Cancer Registry. Codes and search strategies were studied using NPR data from Denmark (population 5.2 million).

Results: In the North Jutland County study, the NPR identified 95% of new patients with histologically verified or probable craniopharyngioma. In the code and search strategy studies, the NPR search identified 684 patients. Records were retrieved in 607 (89%), of whom 185 (30%) had verified or probable craniopharyngioma. Searches combining “”best code”" and “”highly specialized department”" or “”neurosurgery procedure”" registrations improved validity considerably, whereas reducing sensitivity only modestly.

Conclusion: The NPR identified 95% of new craniopharyngioma patients, but only 30% of cases were correct. Validity was improved by applying a modified composite search strategy.