The cut off value was median

The cut off value was median expression of VEGF-C Table 2 Univariate analysis for clinicopathologic variables and mRNA expression of VEGF-C parameter Riskratio 95%aCI p-value Primary tumor       Tis, T1 1 2.11-16.13 < 0.001 T234 5.85     Lymph node metastasis       N0 1 1.66-6.9 < 0.001 N1 3.38     Lymph Invasion       Negative 1 0.98-3.11 0.056 Positive 1.75     Vein invasion       Negative 1 0.96-2.72 0.067 Positive 1.62     VEGF-C expression

      Low expression 1 1.2-3.4 0.0085 High expression 2.02     aCI; confidence interval       Univariate analysis shows that, among the clinico-pathological factors, the extent of the primary tumor, lymph node metastasis, and high expression of VEGF-C are all #Selonsertib randurls[1|1|,|CHEM1|]# statistically significant prognostic factors Table 3 Multivariate analysis for clinicopathologic variables and mRNA expression of VEGF-C parameter Riskratio 95%aCI p-value Primary tumor       Tis, T1 1 1.62-12.7 0.004 T234 4.52     Lymph node metastasis       N0 1 1.14-4.85 0.02 N1 2.36     VEGF-C expression       Low expression 1 0.97-2.78 0.065 High expression 1.64     aCI; confidence interval  

    Multivariate analysis shows that, among the clinico-pathological factors, the extent of the primary tumor and lymph node metastasis are statistically significant prognostic factors We next analyzed a subgroup of patients with Tis and T1 tumors (Table 4). In this subgroup, we examined the relationship between the LCZ696 in vitro clinico-pathological factors and the expression of VEGF-C in ESCC. The expression

of VEGF-C was found to be higher in N1 tumors than in N0 tumors (Table 4, Fig. 4). The expression of VEGF-C was found to be higher in T1 and Stage2A, 2B tumors than in Tis and Stage0-1 tumors (Table. 4). We also examined the relationship between the expression of VEGF-C and the survival data. The patients were divided into two groups according to the expression of VEGF-C. The cut off value was median expression of VEGF-C (a next high expression group of 10 cases and a low expression group of 11 cases). The survival rate of the patients in the high expression group was clearly lower than that in the low expression group, and all the patients in the low VEGF-C expression group were survived (data not shown). Figure 4 The mRNA expression of VEGF-C in Tis and T1 ESCC tumors. The expression of VEGF-C is higher in N1 tumors than in N0 tumors (p = 0.029). Table 4 Relationship between clinicopathological factors and mRNA expression of VEGF-C with Tis, T1tumors       VEGF-C expression       case mean ± sd p-value age ≧65 8 -0.11 ± 0.34 0.15   < 65 13 0.12 ± 0.33   gender male 19 0.06 ± 0.35 0.28   female 2 0.25 ± 0.24   Tfactor Tis 6 -0.02 ± 0.14 0.029   T1 15 0.13 ± 0.35   Nfactor N0 12 -0.15 ± 0.27     N1 9 0.27 ± 0.3 0.003 Stage Stage0 6 -0.23 ± 0.14     Stage1 6 -0.072 ± 0.35     Stage2A 1 -0.09       Stage2B 8 0.31 ± 0.29   Stage0,1 vs Stage2A,2B       0.014 Histrogical Type           well 4 0.45 ± 0.18     moderate 14 -0.1 ± 0.29     poor 3 0.

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