Although unable to

reach consensus on a number of issues,

Although unable to

reach consensus on a number of issues, the working group produced 5 recommendations. The working group offers 2 recommendations addressing the criteria necessary to determine when genetic results JQEZ5 mouse should and may be returned to study participants, respectively. In addition, it suggests that a time limit be established to limit the duration of obligation of investigators to return genetic research results. The group recommends the creation of a central body, or bodies, to provide guidance on when genetic research results are associated with sufficient risk and have established clinical utility to justify their return to study participants. The final recommendation urges investigators to engage the broader community when dealing with identifiable communities to advise them on the return of aggregate

and individual research results. Creation of an entity charged to provide guidance to institutional review boards, investigators, research institutions, and research sponsors would provide rigorous review of available data, promote standardization of study policies regarding return of genetic research results, and enable investigators and study participants to clarify and share expectations for the handling of this increasingly valuable information with appropriate respect for the rights and needs of participants. (Circ Cardiovasc Genet. 2010;3:574-580.)”
“Objective: PS-095760 To examine the prevalence and correlates of substance use during pregnancy among women in the United States.

Methods: We analyzed data from pregnant (n = 1800) and non-pregnant women (n = 37,527) aged

15-44 years who participated in the 2002 or 2003 National Survey on Drug Use and Health, a nationally representative epidemiologic Survey. Study variables included demographics, any Substance use in the prior 30 days, and possible current psychopathology. Data were analyzed using weighted chi-square and multiple logistic regressions that accounted for the complex survey design.

Results: The overall prevalence of any past month substance use during pregnancy was 25.8%; the prevalence rates of past month illicit Selleck VS-6063 drug, cigarette and alcohol use were 4.7%, 18.9%, and 10%, respectively. Compared to the prevalence of substance use among Women in their first trimester, use Was Significantly lower among women in their second or third trimesters. Women who reported using Substances during pregnancy were significantly more likely to meet the criteria for possible current psychopathology and be White. Additionally, women who were employed, married, and in their second or third trimester compared to the first were significantly less likely to have used any Substance during pregnancy, adjusting for age, ethnicity and income.

Although the 3′-CITE of non-adapted MNSV-M alpha 5 is active in s

Although the 3′-CITE of non-adapted MNSV-M alpha 5 is active in susceptible

melon, it does not promote efficient translation in N. benthamiana, thus preventing expression of proteins required for virus replication. However, MNSV-M alpha 5 gains the ability to multiply in N. benthamiana cells if eIF4E from a susceptible melon variety (Cm-eIF4E-S) is supplied in trans. These data show that N. benthamiana resistance to MNSV-M alpha 5 results from incompatibility between the MNSV-M alpha 5 3′-CITE and N. benthamiana eIF4E in initiating efficient translation of CT99021 datasheet the viral genome. Therefore, non-host resistance conferred by the inability of a host susceptibility factor to support viral multiplication may be a possible mechanism for this type of resistance to viruses.”
“Drug delivery in the brain is limited by slow drug diffusion in the brain tissue. This study tested the hypothesis

that ultrasound can safely enhance the permeation of drugs in the brain. In vitro exposure to ultrasound at various frequencies (85 kHz, 174 kHz, and 1 MHz) enhanced the permeation of tritium-labeled molecules with molecular weight MRT67307 mouse up to 70 kDa across porcine brain tissue. A maximum enhancement of 24-fold was observed at 85 kHz and 1,200 J/cm(2). In vivo exposure to 1-MHz ultrasound further demonstrated the ability of ultrasound to facilitate molecule distribution in the brain of a non-human primate. Finally, ultrasound under conditions similar to those used in vivo was shown to cause no damage to plasmid DNA, siRNA, adeno-associated virus, and fetal rat cortical neurons over a range of conditions. Altogether, these studies demonstrate that ultrasound can increase drug permeation in the brain in vitro and in vivo under

conditions that did not cause detectable damage.”
“Abnormal autoimmune activity has been implicated in a number of neuropsychiatric disorders. In this review, the authors discuss a newly recognized class of synaptic autoimmune encephalitides as well as behavioral and cognitive manifestations of systemic autoimmune diseases. (The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:90-97)”
“Changes selleck screening library in the duration, quality and intensity of light affect flowering time. Compared with the effects of light duration and quality, less is known about the effects of light intensity on flowering. Here we describe two paralogous single Myb domain genes, MYB-RELATED PROTEIN 1 (MYR1) and MYB-RELATED PROTEIN 2 (MYR2), and their roles as repressors of responses to decreased light intensity in Arabidopsis. Homozygous myr1 myr2 double mutants flowered early under low light intensities. Additionally, myr1 myr2 mutants exhibited increases in petiole length, leaf angle and apical dominance. Genetic analyses involving mutants in the long-day, gibberellin (GA) and phyB flowering pathways indicated that all aspects of the myr1 myr2 phenotype required GA biosynthesis.

9%) and five fresh and two cryopreserved ICSI-derived embryos res

9%) and five fresh and two cryopreserved ICSI-derived embryos resulting in three clinical pregnancies (42.9%). This research has shown IVF to be a legitimate fertilization technique for IVM

oocytes in PCOS patients and provides a greater awareness of the use of a fertilization method previously not utilized with IVM. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Background: INCB28060 Long-stem tibial components are available for complex primary and revision total knee arthroplasties. Most of the stems’ designs are based on anatomic data from Western populations. We conducted a morphologic study to determine the relationship of the tibial shaft to the tibial plateau in Chinese people.

Methods: We included knees from fifty Chinese individuals (twenty-five females and twenty-five males) in this study. On magnetic resonance imaging scans of the tibial plateau and the proximal part of the tibial shaft of each lower limb, the distance XMU-MP-1 between the axis of

the tibial shaft and the center of the tibial plateau was measured and was defined as the offset of the tibial shaft from the tibial plateau at three resection levels: the first just distal to the subchondral bone of the medial tibial plateau, the second 5 mm distal to it, and the third 10 mm distal to it. The dimensions of the tibial plateau were measured as well.

Results: At the first, second, and third resection levels, the mean tibial shaft offsets (and standard deviations) from the center of the tibial plateau were, respectively, 7.23 +/- 2.44 mm (3.40 +/- 1.94 mm of mediolateral offset and

6.22 +/- 2.05 mm of anteroposterior offset), 6.33 +/- 2.26 mm (3.14 MI-503 order +/- 2.04 mm of mediolateral offset and 5.24 +/- 1.96 mm of anteroposterior offset), and 4.75 +/- 2.07 mm (2.68 +/- 1.91 mm of mediolateral offset and 3.46 +/- 2.03 mm of anteroposterior offset). At each resection level, the mean offset in the male group was significantly larger than that in the female group.

Conclusions: There is a large variation in the offset of the tibial shaft from the tibial plateau in Chinese people. The axis of the tibial shaft is located anterolateral to the center of the tibial plateau in this population.”
“There is a lack of data regarding potential exposure of gametes to bisphenol A during IVF. Detectable concentrations of bisphenol A were not found in commonly used IVF plastic culture dishes, suction tubing or growth media under normal-use conditions. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“It remains controversial whether anti-Mullerian hormone (AMH) concentration is influenced by hormonal contraception. This study quantified the effect of hormonal contraception on both endocrine and sonographic ovarian reserve markers in 228 users and 504 non-users of hormonal contraception.

This paper outlines the evidence for efficacy from randomised

This paper outlines the evidence for efficacy from randomised BMS-754807 cost trials for the most commonly used CRC screening

tests to reduce CRC incidence and mortality in the average-risk population.

Four randomised trials have investigated the effect of guaiac-based fecal occult blood screening on CRC mortality, with a combined CRC mortality risk reduction of 15-17% in an intention-to-screen analysis, and 25% for those people who attended screening. Flexible sigmoidoscopy screening has been evaluated in three randomised trials. The observed reduction in CRC incidence varied between 23 and 80%, and between 27 and 67% for CRC mortality, respectively (intention-to-screen analyses) in the trials with long follow-up time. No randomised trials exist in selleck screening library other CRC screening tools, included colonoscopy screening.

FOBT and flexible sigmoidoscopy are the two CRC screening methods which have been tested in randomised trials and shown to reduce CRC mortality. These tests can be recommended for CRC screening. (C) 2010 Elsevier Ltd. All rights reserved.”
“For high efficiency silicon solar cells, the

rear surface passivation by a dielectric layer has significant advantages compared to the standard fully covered Al back-contact structure. In this work the rear contact formation of the passivated emitter and rear cell device structure is analyzed. Contrary to expected views, we found that the contact resistivity of fine screen printed Al fingers alloyed on narrow p-type Si areas depends VX770 on the geometry of the Al Si alloy formation below the contacts, and decreases by reducing the contact area, while the contact resistance remains constant. At the solar cell level, the reduction in the contact resistivity leads to a minimization of the fill factor losses. At the same time, narrow Al-Si alloy formations increased the passivated area below the contacts, improving the optical properties of the rear side, reducing the short-circuit

current and open-circuit voltage losses. Scanning electron microscopy analysis of the Al-Si alloy geometry is performed, in order to understand its influence on the contact resistivity. The analysis presented in this article has application in Al Si alloying processes and advanced solar cells concepts, like back-contact and rear passivated solar cells. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3437070]“
“The mechanisms by which adaptive phenotypes spread within an evolving population after their emergence are understood fairly well. Much less is known about the factors that influence the evolutionary accessibility of such phenotypes, a pre-requisite for their emergence in a population. Here, we investigate the influence of environmental quality on the accessibility of adaptive phenotypes of Escherichia coli’s central metabolic network.


“We investigated parallel arrays of superconducting Nb/AlO


“We investigated parallel arrays of superconducting Nb/AlO(x)/Nb tunnel junctions nonevenly distributed in a superconducting Nb/SiO/Nb microstrip transmission line. Such devices are discretized Josephson transmission lines (DJTLs) in which, from theory, magnetic flux quanta (“”fluxons”") can travel as solitonic waves when a dc current bias and a dc magnetic field are applied. We observed a reproducible series of resonant branches in each device’s I-V curve, at Josephson submillimeter-wave

frequencies (from 240 to 720 GHz) matching the resonances predicted using a transmission line analysis, where the loading of the N=5 junctions is fully taken into account. The nonperiodic distribution was optimized to provide rf matching over GF120918 a large bandwidth (450-650 GHz typically), implying that the plasma resonance of junctions is inductively tuned out over a similar band www.selleckchem.com/products/poziotinib-hm781-36b.html by the array. A confirmation of this comes from the observation, at frequencies higher than the untuned junctions plasma frequency, of several Josephson phenomena reported

in this article: Fiske-like resonances, phase-locking of the n=3 resonance to an external 600 GHz microwave source, rf-induced zero crossing, and resonances at fractional harmonics of the rf signal. These experimental results are all compatible with a fluxon-based resonances interpretation, as in the extensively studied long Josephson junctions yet at higher frequencies. As reported elsewhere, we could detect similar to 500 GHz microwave radiation emitted by our devices in the n=1 and n=3 modes. In light

of these unique properties, we propose nonuniform DJTLs as a promising type of Josephson device for submillimeter-wave oscillators and fast fluxon-based electronics.”
“A copolymer, poly(L-lactide)-g-poly(N-vinyl pyrrolidone) (PLLA-g-PVP) was prepared with poly(L-lactide) (PLLA) and N-vinyl pyrrolidone in the presence of methanol as a solvent by gamma-ray irradiation. The structure of PLLA-g-PVP was characterized by (1)H-NMR and Fourier transform infrared spectroscopy. The PLLA-g-PVP graft ratio calculated by the percentage increase in weight increased with the increase of absorbed dose, and the percentage JQ1 crystallinity of PLLA-g-PVP decreased with increasing graft ratio. The introduction of the poly(N-vinyl pyrrolidone) chain into PLLA resulted in a decrease in the contact angle of PLLA-g-PVP with increasing graft ratio. In vitro degradation testing showed that PLLA-g-PVP had a higher degradation rate both in the weight-loss test and molecular weight measurement because of a lower crystalline percentage and higher hydrophilicity compared to PLLA. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 3152-3157,2009″
“Objective To determine an effective mode of therapy of ingrown nail using two different methods.

05), but a minimal effect on the breast cancer scale (total effec

05), but a minimal effect on the breast cancer scale (total effect = 0.036, P > 0.05).

Conclusions: The inter-relationships among the three variables give us a better understanding of breast cancer patients’ experience and provide guidance for developing

effective strategies to improve their HRQoL and relieving unpleasant symptoms. (C) 2012 Elsevier Ltd. All rights reserved.”
“Objective. The objective of this study was to assess the influence of different final irrigating solutions on dentin permeability and smear layer removal using the same specimens and relate the results obtained.

Study design. Forty anterior human teeth were instrumented and divided into 4 groups (n = 10) at the final rinse step, according this website to the AZD4547 datasheet irrigant used: G I (control) – 1% NaOCl; G II – 17% EDTA; G III – 17% EDTAT; and G IV – Biopure MTAD. The canals were filled with 0.5% methylene blue and maintained in bottles for 48 hours. The roots were transversally split in coronal, middle, and apical fragments. The specimens were

photographed and analyzed regarding dye penetration. The fragments were then axially split and prepared for SEM. The photomicrographs were analyzed and qualified by scores.

Results. Only the EDTA-T group exhibited statistical difference in which the apical third had less dentin permeability (P < .05). When a decalcifying agent was used, smear layer was removed, which did not happen in the NaOCl group. Regarding smear layer removal, differences were found only in the EDTA group in which the apical third presented more smear layer (P < .05). No correlation was found for both studies (r = 0.4207).

Conclusions. There was not an even relationship between the results from both studies, which inferes that higher or lower dentinal permeability does not necessarily correspond to a higher or lower amount of smear layer. The analysis of dentin permeability and smear layer removal was shown to be a feasible procedure using the same specimens. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: e47-e51)”
“We present eight-band k . p calculations of the electronic and polarization properties of Z-DEVD-FMK manufacturer columnar

InzGa1-zAs quantum dots (CQD) with high aspect ratio embedded in an InxGa1-xAs/GaAs quantum well. Our model accounts for the linear strain effects, linear piezoelectricity, and spin-orbit interaction. We calculate the relative intensities of transverse-magnetic (TM) and transverse-electric (TE) linear polarized light emitted from the edge of the semiconductor wafer as a function of the two main factors affecting the heavy hole-light hole valence band mixing and hence, the polarization dependent selection rules for the optical transitions, namely, (i) the composition contrast z/x between the dot material and the surrounding well and (ii) the dot aspect ratio. The numerical results show that the former is the main driving parameter for tuning the polarization properties.

(C) 2011 Wiley Periodicals, Inc Environ Toxicol 26: 395-402, 201

(C) 2011 Wiley Periodicals, Inc. Environ Toxicol 26: 395-402, 2011.”
“Objective: While the physical and psychosocial benefits of participating in physical activity (PA) during and following breast cancer treatment are well understood, less is known about rates and uptake of PA following diagnosis. This paper explores the levels and patterns of PA among women recently diagnosed with breast cancer and the factors associated with change in activity levels.

Methods: Using a population-based recruitment approach, PA levels of 287 breast cancer patients were assessed at 6, 12 and 18 months post-diagnosis using the Behavioral Risk Factor Surveillance System, and then converted to MET (metabolic

equivalent task)-hours/week. Regression analyses were used to explore the correlates associated with change between SB273005 6 and 18 months post-diagnosis.

Results: Although more than 80% of women participated in PA at each testing phases, more than 50% were considered insufficiently active

or sedentary according to national recommendations and less than one-third reported engagement in vigorous or strength activities. Mean change in total MET-hours/week between 6 and 18 months post-diagnosis was minor (mean = 0.10, median = 0.0), however individual changes were substantial (ranging from – 100 to + 174 MET-hours/week). Results are more encouraging Selleckchem Entinostat for the lower threshold of 3 + MET-hours/week, which may be most relevant specifically for breast cancer outcomes.

Conclusions: Since the majority of women report insufficient levels of PA, there is a clear need for exercise interventions during and following breast cancer treatment. Few ARS-1620 molecular weight characteristics predict declines or improvements in PA levels, hence for optimal benefit, interventions should target the entire breast cancer population. Copyright (C) 2008 John Wiley & Sons, Ltd.”
“BACKGROUND: Gestational diabetes insipidus is a rare, transient complication of pregnancy typically characterized by polyuria and polydipsia that may lead to mild electrolyte abnormalities. More severe sequelae of gestational

diabetes insipidus are uncommon.

CASE: We present a case of a 25-year-old woman at 23 weeks of gestation in a dichorionic-diamniotic twin pregnancy who developed severe symptomatic gestational diabetes insipidus complicated by rhabdomyolysis and death of both fetuses.

CONCLUSION: Maternal rhabdomyolysis caused by gestational diabetes insipidus is extremely rare. Early recognition and treatment of gestational diabetes insipidus is necessary to prevent maternal and fetal morbidity and mortality.”
“Hydroponics experiments were conducted to underpin the nature of interactions between Zn, an essential micronutrient and Pb, a nonessential element on plant growth and root morphology, as well as antioxidant adaptation in mined ecotype (ME) and nonmined ecotype (NME) of Elsholtzia argyi. Plants were exposed to 50 mu M Pb having normal Zn (0.


“In this study, we isolated a new glucoside of the resvera


“In this study, we isolated a new glucoside of the resveratrol trimer

(hopeaside E) from the stem wood of Hopea utilis. The glucoside structure is partially composed of balanocarpol (resveratrol dimer) after oxidative condensation of the (E)-resveratrol-10-C-beta-glucopyranoside. The structure elucidation was achieved by spectroscopic analysis including NMR experiments, and the absolute configuration histone deacetylase activity was determined on the basis of the comparative configurational analysis with the beta-D-glucopyranosyl group. Conformational analysis was also performed by considering deshielding effects due to aromatic rings using computational methods of molecular modeling. The aglycone has six asymmetric carbons with two

aliphatic hydroxyl groups attached to them that has not been reported in any other resveratrol derivative studies. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Background/Aims. Vitamin D(3) is liposoluble, so dietary fat could increase its oral absorption. Our aim was to compare serum 25-hydroxyvitamin D [25(OH) D] after the oral intake of cholecalciferol with a high-or low-fat meal. Methods. In a single-blind, parallel clinical trial, 32 healthy physicians were divided into two groups. In the same day, they ingested 50,000 IU (1.25mg) of vitamin D3 with food: group 1 (G1): lipids: 25.6 g and group 2 (G2) lipids: 1.7 g. Serum 25(OH) D (0, 7, and 14 days), LY3039478 Stem Cells & Wnt inhibitor and parathyroid hormone (PTH), and calcium (0 and 14 days) were measured. Results. Baseline mean serum 25(OH) D levels were 42.7 +/- 19.0 nmol/L in G1 and 36.4 +/- 19.0 nmol/L in G2 (P = 0.38). After cholecalciferol, mean serum 25(OH) D was higher in G1 (P < 0.001): 7 days: G1 = 46.2 (38.4-53.9)

nmol/L and G2 = 33.7 (25.4-40.1) nmol/L; 14 days: G1 Fer-1 = 53.7 (45.2-62.1) nmol/L and G2 = 33.7 (25.2-42.2) nmol/L. Serum PTH and 25(OH) D were negatively correlated before and after the intake of vitamin D(3), respectively, r = -0.42 (P = 0.02) and r = -0.52 (P = 0.003). Conclusions. A high-fat meal increased the absorption of vitamin D3, as measured by serum 25(OH) D.”
“Two new acylated dolabellane-type diterpenes, nigellamines B-3 (9) and D (10), were isolated from Nigella sativa (Ranunculaceae) seeds using column chromatography and preparative HPLC. Their structures were determined based on chemical and physicochemical evidence, and confirmed using previously isolated related compounds as reference. Of the seed constituents, nigellamines A(2) (2), A(3) (3), A(5) (5), B-1 (6), and B-2 (7) had in vitro triglyceride metabolism-promoting activities in the high glucose-pretreated human liver carcinoma cell line, HepG2. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V.

A total of 1,703 patients met the study criteria, and the inciden

A total of 1,703 patients met the study criteria, and the incidence of

complete amiodarone monitoring for all patients was 7.6 %. The least common monitoring test performed was triiodothyronine at 19.4 %, and the most common was electrocardiogram at 89.7 %. Critically ill patients and neonates were more likely to have amiodarone monitoring. Considerable variation in monitoring practices between pediatric hospitals was identified. Monitoring of amiodarone therapy in patients admitted to pediatric hospitals is low. Future efforts to standardize selleck chemical care are warranted.”
“Background. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice. Objective. To provide information about the relationship between semen parameters and spontaneous conception. Methods. We evaluated retrospectively 453 pregnancies that occurred among 2935 infertile couples evaluated at an infertility clinic of a tertiary-care university hospital, between 2004 and 2009. Results. Normal semen analysis was present only in 158 patients; 295 subfertile patients showed alterations in at least one seminal parameter. A reduction in all seminal parameters was observed in 41 patients. Etiological causes of male infertility were identified in 314 patients. Conclusion. Our data highlights the possibility of

a spontaneous conception with semen parameters below WHO reference values. Therefore, we support the importance of defining reference values on a population of fertile men. Finally, www.selleckchem.com/screening/autophagy-signaling-compound-library.html we analyzed the related ethical issues.”
“Neo-aortic arch obstruction (NAAO) is a common complication following the Norwood/Sano procedure (NP) for hypoplastic left heart syndrome (HLHS) and is associated with increased morbidity and mortality. However, there is currently no objective method for predicting which patients will develop NAAO. This study was designed to test the hypothesis that hemodynamic changes from development of NAAO after NP in patients with HLHS AC220 supplier will lead to changes in myocardial dynamics that could

be detected before clinical symptoms develop with strain analysis using velocity vector imaging. Patients with HLHS who had at least one cardiac catheterization after NP were identified retrospectively. Strain analysis was performed on all echocardiograms preceding the first catheterization and any subsequent catheterization performed for intervention on NAAO. Twelve patients developed NAAO and 30 patients never developed NAAO. Right ventricular strain was worse in the group that developed NAAO (-6.2 vs. -8.6 %, p = 0.040) at a median of 59 days prior to diagnosis of NAAO. Those patients that developed NAAO following NP were significantly younger at the time of first catheterization than those that did not develop NAAO (92 +/- A 50 vs. 140 +/- A 36 days, p = 0.001).

Moreover, using three independent sets of data (collected

Moreover, using three independent sets of data (collected LY3039478 from ice-cores and chemistry) we perform a specific regression analysis which concludes that forecasts about the correlation between CO2-concentration and temperature rely heavily on the choice of data used, and one cannot be positive that indeed such a correlation exists (for chemistry data) or even, if existing (for ice-cores data), whether it leads to a “”severe”" or a “”gentle”" global warming. A very recent development on the greenhouse phenomenon is a validated adiabatic model, based on laws of physics, forecasting a maximum temperature-increase of 0.01-0.03 degrees C for a value doubling the

present concentration of atmospheric CO2. Through a further review of related studies and facts from disciplines like biology and geology, where CO2-change is viewed from a different perspective, it is suggested that

CO2-change is not necessarily always a negative factor for the environment. In fact it is shown that CO2-increase has stimulated the growth of plants, while the CO2-change history has altered the physiology of plants. Moreover, data from palaeoclimatology show that the CO2-content in the atmosphere is at a minimum in this geological aeon. Finally it is stressed that the understanding of the functioning of Earth’s complex climate system (especially for water, solar radiation and so forth) is still poor and, hence, scientific knowledge is not at a level to give definite and precise answers for the causes of global warming. (C) 2008 Elsevier Ltd. All rights reserved.”
“Objective. There find more is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child

pairs, the Pregnancy Outcomes and Community Health Study assessed 10 functional polymorphisms in 9 genes involved in innate immune function.

Methods. Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD learn more subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions.

Results. Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-C1562T, and TNF receptor two M196R (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p < 0.05). Among African-American women, the odds of PTD were higher when both mother and child carried the TNFR2 R allele (multiplicative interaction p < 0.05).

Conclusion.